『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.志内 哲也 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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2. (英) Miyatake Yumiko (日) (読)
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3. (英) Otsuka Airi (日) 大塚 愛理 (読) おおつか あいり
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学籍番号 (推奨): **** [ユーザ]
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4.近久 幸子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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5.阪上 浩 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.代謝栄養学]/[糖尿病臨床・研究開発センター])
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6.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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題名 (必須): (英) Role of orexin in exercise-induced leptin sensitivity in the mediobasal hypothalamus of mice.  (日)    [継承]
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要約 (任意): (英) Orexin is known as an important neuropeptide in the regulation of energy metabolism. However, the role of orexin in exercise-induced leptin sensitivity in the hypothalamus has been unclear. In this study, we determined the effect of transient treadmill exercise on leptin sensitivity in the mediobasal hypothalamus (MBH) of mice and examined the role of orexin in post-exercise leptin sensitivity. Treadmill running for 45min increased the orexin neuron activity in mice. Intraperitoneal injection of a submaximal dose of leptin after exercise stimulated the phosphorylation of signal transducer and activator of transcription 3 (STAT3) in MBH of mice post-exercise compared with that in non-exercised mice, although intracerebroventricular (icv) injection of leptin did not enhance STAT3 phosphorylation, even after exercise. Icv injection of an orexin receptor antagonist, SB334867 reduced STAT3 phosphorylation, which was enhanced by icv injection of orexin but not by direct injection of orexin into MBH. Exercise increased the phosphorylation of extracellular signal-regulated kinases (ERKs) in the MBH of mice, while ERK phosphorylation was reduced by SB334867. Leptin injection after exercise increased the leptin level in MBH, whereas icv injection of SB334867 suppressed the increase in the leptin level in MBH of mice. These results indicate that the activation of orexin neurons by exercise may contribute to the enhancement of leptin sensitivity in MBH. This effect may be mediated by increased transportation of circulating leptin into MBH, with the involvement of ERK phosphorylation.  (日)    [継承]
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誌名 (必須): Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)

ISSN (任意): 1090-2104
ISSN: 0006-291X (pISSN: 0006-291X, eISSN: 1090-2104)
Title: Biochemical and biophysical research communications
Title(ISO): Biochem. Biophys. Res. Commun.
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2019年 4月 25日 (平成 31年 4月 25日) [継承]
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DOI (任意): 10.1016/j.bbrc.2019.04.145    (→Scopusで検索) [継承]
PMID (任意): 31029425    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Tetsuya Shiuchi, Yumiko Miyatake, Airi Otsuka, Sachiko Chikahisa, Hiroshi Sakaue and Hiroyoshi Sei : Role of orexin in exercise-induced leptin sensitivity in the mediobasal hypothalamus of mice., Biochemical and Biophysical Research Communications, Vol.514, No.1, 166-172, 2019.
欧文冊子 ● Tetsuya Shiuchi, Yumiko Miyatake, Airi Otsuka, Sachiko Chikahisa, Hiroshi Sakaue and Hiroyoshi Sei : Role of orexin in exercise-induced leptin sensitivity in the mediobasal hypothalamus of mice., Biochemical and Biophysical Research Communications, Vol.514, No.1, 166-172, 2019.

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