『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=353486EID:353486, Map:0, LastModified:2019年8月19日(月) 18:32:04, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[松井 尚子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
共著種別 (推奨): 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) [継承]
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Fumitaka Shimizu (日) (読)
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2. (英) Mariko Oishi (日) (読)
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3. (英) Setsu Sawai (日) (読)
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4. (英) Minako Beppu (日) (読)
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5. (英) Sonoko Misawa (日) (読)
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6.松井 尚子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.医療教育学])
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7.宮城 愛
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8. (英) Toshihiko Maeda (日) (読)
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9. (英) Yukio Takeshita (日) (読)
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10. (英) Hideaki Nishihara (日) (読)
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11. (英) Yasuteru Sano (日) (読)
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12. (英) Ryota Sato (日) (読)
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13.梶 龍兒
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14. (英) Satoshi Kuwabara (日) (読)
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15. (英) Takashi Kanda (日) (読)
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題名 (必須): (英) Increased IP-10 production by blood-nerve barrier in multifocal acquired demyelinating sensory and motor neuropathy and multifocal motor neuropathy  (日)    [継承]
副題 (任意):
要約 (任意): (英) Dysfunction of the blood-nerve barrier (BNB) plays important roles in chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN). The aim of the present study was to identify the candidate cytokines/chemokines that cause the breakdown of the BNB using sera from patients with CIDP and MMN. We determined the levels of 27 cytokines and chemokines in human peripheral nerve microvascular endothelial cells (PnMECs) after exposure to sera obtained from patients with CIDP variants (typical CIDP and multifocal acquired demyelinating sensory and motor neuropathy [MADSAM]), MMN and amyotrophic lateral sclerosis (ALS), and healthy controls (HC), using a multiplexed fluorescent bead-based immunoassay system. The induced protein (IP)10 level in the cells in both the MADSAM and MMN groups was markedly increased in comparison with the typical CIDP, ALS and HC groups. The other cytokines, including granulocyte colony-stimulating factor,vascular endothelial growth factor (VEGF) and interleukin-7, were also significantly upregulated in the MADSAM group. The increase of IP-10 produced by PnMECs was correlated with the presence of conduction block in both the MADSAM and MMN groups. The autocrine secretion of IP-10 induced by patient sera in PnMECs was markedly upregulated in both the MADSAM and MMN groups. The overproduction of IP-10 by PnMECs leads to the focal breakdown of the BNB and may help to mediate the transfer of pathogenic T cells across the BNB, thereby resulting in the appearance of conduction block in electrophysiological studies of patients with MADSAM and MMN.  (日)    [継承]
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誌名 (必須): Journal of Neurology, Neurosurgery, and Psychiatry (British Medical Association)
(pISSN: 0022-3050, eISSN: 1468-330X)

ISSN (任意): 1468-330X
ISSN: 0022-3050 (pISSN: 0022-3050, eISSN: 1468-330X)
Title: Journal of neurology, neurosurgery, and psychiatry
Title(ISO): J Neurol Neurosurg Psychiatry
Publisher: BMJ Group
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 90 [継承]
(必須): 4 [継承]
(必須): 444 450 [継承]
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年月日 (必須): 西暦 2018年 12月 6日 (平成 30年 12月 6日) [継承]
URL (任意):
DOI (任意): 10.1136/jnnp-2018-319270    (→Scopusで検索) [継承]
PMID (任意): 30523038    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1136/jnnp-2018-319270  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) KeywordList.Keyword: IP-10  (日)    [継承]
4.(英) KeywordList.Keyword: blood-nerve barrier  (日)    [継承]
5.(英) KeywordList.Keyword: chronic inflammatory demyelinating polyneuropathy  (日)    [継承]
6.(英) KeywordList.Keyword: conduction block  (日)    [継承]
7.(英) KeywordList.Keyword: multifocal motor neuropathy  (日)    [継承]
8.(英) CoiStatement: Competing interests: None declared.  (日)    [継承]

標準的な表示

和文冊子 ● Shimizu Fumitaka, Oishi Mariko, Sawai Setsu, Beppu Minako, Misawa Sonoko, Naoko Matsui, Ai Miyashiro, Maeda Toshihiko, Takeshita Yukio, Nishihara Hideaki, Sano Yasuteru, Sato Ryota, Ryuji Kaji, Kuwabara Satoshi and Kanda Takashi : Increased IP-10 production by blood-nerve barrier in multifocal acquired demyelinating sensory and motor neuropathy and multifocal motor neuropathy, Journal of Neurology, Neurosurgery, and Psychiatry, Vol.90, No.4, 444-450, 2018.
欧文冊子 ● Shimizu Fumitaka, Oishi Mariko, Sawai Setsu, Beppu Minako, Misawa Sonoko, Naoko Matsui, Ai Miyashiro, Maeda Toshihiko, Takeshita Yukio, Nishihara Hideaki, Sano Yasuteru, Sato Ryota, Ryuji Kaji, Kuwabara Satoshi and Kanda Takashi : Increased IP-10 production by blood-nerve barrier in multifocal acquired demyelinating sensory and motor neuropathy and multifocal motor neuropathy, Journal of Neurology, Neurosurgery, and Psychiatry, Vol.90, No.4, 444-450, 2018.

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