『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
共著種別 (推奨): 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) [継承]
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Jianwei Wang (日) (読)
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2. (英) Sekai Miho (日) (読)
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3. (英) Matsui Takeshi (日) (読)
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4. (英) Fujii Yosuke (日) (読)
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5.松本 満 ([徳島大学.先端酵素学研究所.重点研究部門])
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6. (英) Takeuchi Osamu (日) (読)
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7. (英) Minato Nagahiro (日) (読)
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8. (英) Hamazaki Yoko (日) (読)
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題名 (必須): (英) Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus  (日)    [継承]
副題 (任意):
要約 (任意): (英) Hassall's corpuscles (HCs) are composed of cornifying, terminally differentiated medullary thymic epithelial cells (mTECs) that are developed under the control of Aire. Here, we demonstrated that HC-mTECs show features of cellular senescence and produce inflammatory cytokines and chemokines including CXCL5, thereby recruiting and activating neutrophils to produce IL-23 in the thymic medulla. We further indicated that thymic plasmacytoid dendritic cells (pDCs) expressing IL-23 receptors constitutively produced Ifna, which plays a role in single positive (SP) cell maturation, in an Il23a-dependent manner. Neutrophil depletion with anti-Ly6G antibody injection resulted in a significant decrease of Ifna expression in the thymic pDCs, suggesting that thymic neutrophil activation underlies the Ifna expression in thymic pDCs in steady state conditions. A New Zealand White mouse strain showing HC hyperplasia exhibited greater numbers and activation of thymic neutrophils and pDCs than B6 mice, whereas Aire-deficient B6 mice with defective HC development and SP thymocyte maturation showed significantly compromised numbers and activation of these cells. These results collectively suggested that HC-mTECs with cell-senescence features initiate a unique cell activation cascade including neutrophils and pDCs leading to the constitutive IFNα expression required for SP T-cell maturation in the thymic medulla.  (日)    [継承]
キーワード (推奨):
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誌名 (必須): International Immunology ([Oxford University Press])
(pISSN: 0953-8178, eISSN: 1460-2377)

ISSN (任意): 1460-2377
ISSN: 0953-8178 (pISSN: 0953-8178, eISSN: 1460-2377)
Title: International immunology
Title(ISO): Int Immunol
Supplier: Oxford University Press
Publisher: Oxford University Press
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 31 [継承]
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(必須): 127 139 [継承]
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年月日 (必須): 西暦 2019年 3月 5日 (平成 31年 3月 5日) [継承]
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DOI (任意): 10.1093/intimm/dxy073    (→Scopusで検索) [継承]
PMID (任意): 30534943    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-85062891763 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1093/intimm/dxy073  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) KeywordList.Keyword: Hassall's bodies  (日)    [継承]
4.(英) KeywordList.Keyword: cell senescence  (日)    [継承]
5.(英) KeywordList.Keyword: mTEC  (日)    [継承]
6.(英) KeywordList.Keyword: thymic epithelial cells  (日)    [継承]
7.(英) KeywordList.Keyword: type I interferon  (日)    [継承]

標準的な表示

和文冊子 ● Wang Jianwei, Miho Sekai, Takeshi Matsui, Yosuke Fujii, Mitsuru Matsumoto, Osamu Takeuchi, Nagahiro Minato and Yoko Hamazaki : Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus, International Immunology, Vol.31, No.3, 127-139, 2019.
欧文冊子 ● Wang Jianwei, Miho Sekai, Takeshi Matsui, Yosuke Fujii, Mitsuru Matsumoto, Osamu Takeuchi, Nagahiro Minato and Yoko Hamazaki : Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus, International Immunology, Vol.31, No.3, 127-139, 2019.

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