| EID=352298 | EID:352298,
Map:0,
LastModified:2019年12月25日(水) 15:11:22,
Operator:[三木 ちひろ],
Avail:TRUE,
Censor:0,
Owner:[松久 宗英],
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| ○種別 (必須): | □ | 学術論文 (紀要その他)
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| ○言語 (必須): | □ | 日本語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Kawano Tomoharu (日) 河野 友晴 (読)
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| 2. | 松久 宗英 ([徳島大学.先端酵素学研究所.基幹研究部門]/徳島大学病院アンチエイジングセンター センター長(併任))
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| 3. | 橋田 誠一 ([宮崎医科大学])
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| 4. | (英) Numata Satoshi (日) 沼田 聡 (読)
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| 5. | 藤本 一幸
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| 6. | 黒田 暁生 ([徳島大学.先端酵素学研究所.基幹研究部門])
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| 7. | (英) Yasuda Tetsuyuki (日) 安田 哲行 (読)
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| 8. | (英) Miyashita Kazuyuki (日) 宮下 和幸 (読)
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| 9. | (英) Sakamoto Fumie (日) 坂本 扶美枝 (読)
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| 10. | (英) Katakami Naoto (日) 片上 直人 (読)
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| 11. | (英) Matsuoka Taka-aki (日) 松岡 孝昭 (読)
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| ○題名 (必須): | □ | (英) Development of highly sensitive enzyme immunoassay (ICT-EIA) for IA-2 autoantibody and application for detection of three islet-specific autoantibodies ( GADA, IA-2A and IAA) in type I diabetes mellitus (日) IA-2抗体の高感度検出法(ICT-EIA法)の開発と長期罹患若年性1型糖尿病患者における3種膵島関連自己抗体(GADA,IA-2A,IAA)の検出について
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) <p>Development of highly sensitive enzyme immunoassay (ICT-EIA) for IA-2 autoantibody and application for detection of three islet-specific autoantibodies ( GADA, IA-2A and IAA) in type I diabetes mellitus Tomoharu Kawano, Satoshi Numata, Yuki Fujimoto, Akio Kuroda, Tetsuyuki Yasuda,Kazuyuki Miyashita, Fumie Sakamoto, Naoto Katakami, Taka-aki Matsuoka, Munehide Matsuhisa and Seiichi Hashida Summary Detection of pancreatic islet-related autoantibodies( insulin antibody [IAA]; glutamic acid decarboxylase antibody [GADA]; and islet antigen-2 antibody [IA-2A], is essential for the diagnosis and prediction of the onset of type I diabetes mellitus. Depending on the disease duration, the detection rate of each autoantibody is different, and using only one kind of autoantibody detection risks overlooking a positive result. The detection precision of type I diabetes mellitus would thus be improved by measuring all three kinds of autoantibodies. We developed a highly sensitive enzyme immunoassay( ICT-EIA) for IA-2 autoantibody. ICT-EIAs for IAA and GADA have already been developed. Using three ICT-EIAs, we attempted to measure autoantibodies in sera from patients with type I diabetes mellitus. Patients comprised 25 males and 51 females( mean age, 33.3±5.7 years; disease duration, 23.9±6.7 years) with type I diabetes mellitus who had been undergoing treatment with insulin for between 11 and 40 years. Among these patients, urinary C-peptide-positive results were seen in three patients. IAA, GADA and IA-2A in sera were measured by ICT-EIA. The newly developed ICT-EIA for IA-2 antibodies was approximately 100-times more sensitive than the conventional ELISA. The positive ratio was 77.6%, representing a high rate of detection. In addition, even in patients with a disease duration >30 years, the positive rate was 64.3%. ICT-EIA was thus suggested to be useful in combination assays for pancreatic islet-related autoantibodies (IAA, GADA and IA-2A).</p><p> </p><p></p> (日) <p>Development of highly sensitive enzyme immunoassay (ICT-EIA) for IA-2 autoantibody and application for detection of three islet-specific autoantibodies ( GADA, IA-2A and IAA) in type I diabetes mellitus Tomoharu Kawano, Satoshi Numata, Yuki Fujimoto, Akio Kuroda, Tetsuyuki Yasuda,Kazuyuki Miyashita, Fumie Sakamoto, Naoto Katakami, Taka-aki Matsuoka, Munehide Matsuhisa and Seiichi Hashida Summary Detection of pancreatic islet-related autoantibodies( insulin antibody [IAA]; glutamic acid decarboxylase antibody [GADA]; and islet antigen-2 antibody [IA-2A], is essential for the diagnosis and prediction of the onset of type I diabetes mellitus. Depending on the disease duration, the detection rate of each autoantibody is different, and using only one kind of autoantibody detection risks overlooking a positive result. The detection precision of type I diabetes mellitus would thus be improved by measuring all three kinds of autoantibodies. We developed a highly sensitive enzyme immunoassay( ICT-EIA) for IA-2 autoantibody. ICT-EIAs for IAA and GADA have already been developed. Using three ICT-EIAs, we attempted to measure autoantibodies in sera from patients with type I diabetes mellitus. Patients comprised 25 males and 51 females( mean age, 33.3±5.7 years; disease duration, 23.9±6.7 years) with type I diabetes mellitus who had been undergoing treatment with insulin for between 11 and 40 years. Among these patients, urinary C-peptide-positive results were seen in three patients. IAA, GADA and IA-2A in sera were measured by ICT-EIA. The newly developed ICT-EIA for IA-2 antibodies was approximately 100-times more sensitive than the conventional ELISA. The positive ratio was 77.6%, representing a high rate of detection. In addition, even in patients with a disease duration >30 years, the positive rate was 64.3%. ICT-EIA was thus suggested to be useful in combination assays for pancreatic islet-related autoantibodies (IAA, GADA and IA-2A).</p><p> </p><p></p>
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| ○キーワード (推奨): |
| ○発行所 (推奨): | □ | 徳島文理大学
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| ○誌名 (必須): | □ | 徳島文理大学研究紀要 ([徳島文理大学])
(pISSN: 0286-9829)
| ○ISSN (任意): | □ | 0286-9829
ISSN: 0286-9829
(pISSN: 0286-9829) Title: 徳島文理大学研究紀要Supplier: 徳島文理大学 (Webcat Plus)
(医中誌Web)
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| ○巻 (必須): | □ | 96
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 35 44
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2018年 9月 初日 (平成 30年 9月 初日)
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| ○URL (任意): | □ | https://ci.nii.ac.jp/naid/130007602165/
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| ○DOI (任意): | □ | 10.24596/tokusimabunriu.96.0_35 (→Scopusで検索)
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| ○PMID (任意): |
| ○NAID (任意): | □ | 130007602165
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