| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Miyamoto Yoshihiko (日) 宮本 佳彦 (読) みやもと よしひこ
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 六車 直樹
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| 3. | (英) Fujimoto Shota (日) 藤本 将太 (読) ふじもと しょうた
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| ○学籍番号 (推奨): | □ | ****
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| 4. | (英) Okada Yasuyuki (日) 岡田 泰行 (読) おかだ やすゆき
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| ○学籍番号 (推奨): | □ | ****
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| 5. | 喜田 慶史 ([徳島大学.大学院医歯薬学研究部.医学域.先端臨床医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| ○学籍番号 (推奨): | □ | ****
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| 6. | 中村 文香
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| ○学籍番号 (推奨): | □ | ****
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| 7. | 田中 久美子
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| 8. | 中川 忠彦
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| 9. | 北村 晋志
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| 10. | 岡本 耕一 ([徳島大学.病院.診療科.内科.消化器内科])
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| 11. | 宮本 弘志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学]/[徳島大学.病院.診療科.内科.消化器内科])
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| 12. | 佐藤 康史 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域消化器・総合内科学])
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| 13. | 高山 哲治 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| ○題名 (必須): | □ | (英) Epidermal growth factor receptortargeted molecular imaging of colorectal tumors: Detection and treatment evaluation of tumors in animal models. (日)
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| ○要約 (任意): | □ | (英) To overcome the problem of overlooking colorectal tumors, a new and highly sensitive modality of colonoscopy is needed. Moreover, it is also important to establish a new modality to evaluate viable tumor volume in primary lesions of colorectal cancer (CRC) during chemotherapy. Therefore, we carried out molecular imaging of colorectal tumors targeting epidermal growth factor receptor (EGFR), which is highly expressed on tumor cells, for evaluating chemotherapeutic efficacy and for endoscopic detection of colorectal adenomas. We first attempted to image five CRC cell lines with various levels of EGFR expression using an Alexa Fluor-labeled anti-EGFR monoclonal antibody (AF-EGFR-Ab). A strong fluorescence signal was observed in the cells depending on the level of EGFR expression. When nude mice xenografted with LIM1215 CRC cells, which highly express EGFR, were i.v. injected with AF-EGFR-Ab, a strong fluorescence signal appeared in the tumor with a high signal to noise ratio, peaking at 48 hours after injection and then gradually decreasing, as shown using an IVIS Spectrum system. When the xenografted mice were treated with 5-fluorouracil, fluorescence intensity in the tumor decreased in proportion to the viable tumor cell volume. Moreover, when the colorectum of azoxymethane-treated rats was observed using a thin fluorescent endoscope with AF-EGFR-Ab, all 10 small colorectal adenomas (3 mm) were detected with a clear fluorescence signal. These preliminary results of animal experiments suggest that EGFR-targeted fluorescent molecular imaging may be useful for quantitatively evaluating cell viability in CRC during chemotherapy, and also for detecting small adenomas using a fluorescent endoscope. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antineoplastic Agents (日) (読)
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| 3. | (英) Azoxymethane (日) (読)
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| 4. | (英) Cell Line, Tumor (日) (読)
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| 5. | (英) Cell Survival (日) (読)
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| 6. | (英) Colorectal Neoplasms (日) (読)
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| 7. | (英) ErbB Receptors (日) (読)
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| 8. | 女性 (female)
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| 9. | (英) Fluorouracil (日) (読)
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| 10. | (英) HT29 Cells (日) (読)
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| 11. | (英) Humans (日) (読)
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| 12. | 男性 (male)
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| 13. | (英) Mice, Inbred BALB C (日) (読)
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| 14. | (英) Mice, Nude (日) (読)
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| 15. | (英) Molecular Targeted Therapy (日) (読)
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| 16. | (英) Rats, Inbred F344 (日) (読)
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| 17. | (英) Xenograft Model Antitumor Assays (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Cancer Science ([日本癌学会])
(pISSN: 1347-9032, eISSN: 1349-7006)
| ○ISSN (任意): | □ | 1349-7006
ISSN: 1347-9032
(pISSN: 1347-9032, eISSN: 1349-7006) Title: Cancer scienceTitle(ISO): Cancer SciPublisher: Wiley-Blackwell (NLM Catalog)
(医中誌Web)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 110
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 1921 1930
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2019年 4月 初日 (平成 31年 4月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1111/cas.14020 (→Scopusで検索)
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| ○PMID (任意): | □ | 30973663 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-85066789077
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| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1111/cas.14020 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: colorectal cancer (日)
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| 4. | (英) KeywordList.Keyword: epidermal growth factor receptor (日)
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| 5. | (英) KeywordList.Keyword: fluorescence endoscopy (日)
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| 6. | (英) KeywordList.Keyword: molecular imaging (日)
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| 7. | (英) KeywordList.Keyword: therapeutic efficacy (日)
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