| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学 (2015年4月1日〜)
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| ○著者 (必須): | 1. | 牛尾 綾 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])
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| 2. | 新垣 理恵子
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| 3. | (英) Ohtsuka Kunihiro (日) 大塚 邦紘 (読) おおつか くにひろ
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| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 4. | 山田 安希子
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| 5. | 常松 貴明 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])
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| 6. | 工藤 保誠 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])
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| 7. | 青田 桂子 ([徳島大学.病院.診療科.歯科口腔外科.口腔内科])
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| 8. | 東 雅之
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| 9. | 石丸 直澄 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])
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| ○題名 (必須): | □ | (英) CCL22-Producing Resident Macrophages Enhance T Cell Response in Sjögren's Syndrome. (日)
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| ○要約 (任意): | □ | (英) Macrophages (MΦs) are critical regulators of immune response and serve as a link between innate and acquired immunity. The precise mechanism of involvement of tissue-resident MΦs in the pathogenesis of autoimmune diseases is not clear. Here, using a murine model for Sjögren's syndrome (SS), we investigated the role of tissue-resident MΦs in the onset and development of autoimmunity. Two unique populations of CD11b and CD11b resident MΦs were observed in the target tissue of the SS model. Comprehensive gene expression analysis of chemokines revealed effective production of CCL22 by the CD11b MΦs. CCL22 upregulated the migratory activity of CD4 T cells by increasing CCR4, a receptor of CCL22, on T cells in the SS model. In addition, CCL22 enhanced IFN-γ production of T cells of the SS model, thereby suggesting that CCL22 may impair the local immune tolerance in the target organ of the SS model. Moreover, administration of anti-CCL22 antibody suppressed autoimmune lesions in the SS model. Finally, histopathological analysis revealed numerous CCL22-producing MΦs in the minor salivary gland tissue specimens of the SS patients. CCL22-producing tissue-resident MΦs may control autoimmune lesions by enhancing T cell response in the SS model. These results suggest that specific chemokines and their receptors may serve as novel therapeutic or diagnostic targets for SS. (日)
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| ○誌名 (必須): | □ | Frontiers in Immunology (Frontiers Research Foundation)
(eISSN: 1664-3224)
| ○ISSN (任意): | □ | 1664-3224
ISSN: 1664-3224
(eISSN: 1664-3224) Title: Frontiers in immunologyTitle(ISO): Front ImmunolPublisher: Frontiers Media S.A. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 9
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 2594 2594
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2018年 11月 8日 (平成 30年 11月 8日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3389/fimmu.2018.02594 (→Scopusで検索)
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| ○PMID (任意): | □ | 30467506 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-85056303968
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.3389/fimmu.2018.02594 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Sjögren's syndrome (日)
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| 4. | (英) KeywordList.Keyword: T cell response (日)
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| 5. | (英) KeywordList.Keyword: autoimmunity (日)
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| 6. | (英) KeywordList.Keyword: chemokine (日)
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| 7. | (英) KeywordList.Keyword: salivary gland (日)
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| 8. | (英) KeywordList.Keyword: tissue-resident macrophage (日)
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