『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.西野 豪志 ([徳島大学.病院.先端医療開発研究プロジェクト]/[徳島大学.病院.診療科.外科.食道・乳腺甲状腺外科])
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[継承]
2.吉田 卓弘 ([徳島大学.病院.診療科.外科.食道・乳腺甲状腺外科])
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3.後藤 正和 ([徳島大学.大学院医歯薬学研究部.医学域.先端臨床医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.胸部・内分泌・腫瘍外科学])
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4.井上 聖也 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.胸部・内分泌・腫瘍外科学])
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5. (英) Minato Takuya (日) 湊 拓也 (読)
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6. (英) Fujiwara Satoshi (日) 藤原 聡史 (読)
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7.山本 洋太
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8.古北 由仁
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9. (英) Yuasa Yasuhiro (日) 湯浅 康弘 (読)
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10. (英) Yamai Hiromichi (日) 山井 礼道 (読)
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11.武知 浩和
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12.鳥羽 博明 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.胸部・内分泌・腫瘍外科学])
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13.滝沢 宏光 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.胸部・内分泌・腫瘍外科学]/[徳島大学.病院.診療科.外科.呼吸器外科])
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14.吉田 光輝 ([徳島大学.病院.診療科.外科.呼吸器外科]/[徳島大学.病院.診療科.外科.食道・乳腺甲状腺外科])
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15.清家 純一
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16.三好 孝典
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17.丹黒 章 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.胸部・内分泌・腫瘍外科学])
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題名 (必須): (英) The effects of the herbal medicine Daikenchuto (TJ-100) after esophageal cancer resection, open-label, randomized controlled trial  (日)    [継承]
副題 (任意):
要約 (任意): (英) Daikenchuto (TJ-100), a traditional Japanese herbal medicine, is widely used in Japan. Its effects on gastrointestinal motility and microcirculation and its anti-inflammatory effect are known. The purpose of this prospective randomized controlled trial was to investigate the effect of TJ-100 after esophagectomy in esophageal cancer patients. Forty patients for whom subtotal esophageal resection for esophageal cancer was planned at our institute from March 2011 to August 2013 were enrolled and divided into two groups at the point of determination of the operation schedule after informed consent was obtained: a TJ-100 (15 g/day)-treated group (n = 20) and a control group (n = 20). The primary efficacy end-points were maintenance of the nutrition condition and the recovery of gastrointestinal function. The secondary efficacy end-points were the serum C-reactive protein (CRP) level and adrenomedullin level during the postoperative course, the incidence of postoperative complications, and the length of hospital stay after surgery. We examined 39 patients because one patient in the TJ-100 group was judged as having unresectable cancer after surgery. The mean age of the TJ-100 group patients was significantly older than that of the control group patients.The rate of body weight decrease at postoperative day 21 was significantly suppressed in the TJ-100 group (3.6% vs. the control group: 7.0%, p = 0.014), but the serum albumin level was not significantly different between the groups. The recovery of gastrointestinal function regarding flatus, defecation, and oral intake showed no significant between-group differences, but postoperative bowel symptoms tended to be rare in the TJ-100 group. There was no significant between-group difference in the length of hospital stay after surgery. The serum CRP level at postoperative day 3 was 4.9 mg/dl in the TJ-100 group and 6.9 mg/dl in the control group, showing a tendency of a suppressed serum CRP level in the TJ-100 group (p = 0.126). The rate of increase in adrenomedullin tended to be high postoperatively, but there was no significant difference between the two groups. TJ-100 treatment after esophageal cancer resection has the effects of prompting the recovery of gastrointestinal motility and minimizing body weight loss, and it might suppress the excess inflammatory reaction related to surgery.  (日)    [継承]
キーワード (推奨): 1. (英) Adrenomedullin (日) (読) [継承]
2. (英) Aged (日) (読) [継承]
3. (英) C-Reactive Protein (日) (読) [継承]
4. (英) Defecation (日) (読) [継承]
5. (英) Eating (日) (読) [継承]
6. (英) Esophageal Neoplasms (日) (読) [継承]
7. (英) Esophagectomy (日) (読) [継承]
8. (英) Female (日) (読) [継承]
9. (英) Gastrointestinal Tract (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11. (英) Length of Stay (日) (読) [継承]
12. (英) Male (日) (読) [継承]
13. (英) Middle Aged (日) (読) [継承]
14. (英) Nutritional Status (日) (読) [継承]
15. (英) Phytotherapy (日) (読) [継承]
16. (英) Plant Extracts (日) (読) [継承]
17. (英) Postoperative Complications (日) (読) [継承]
18. (英) Prospective Studies (日) (読) [継承]
19. (英) Recovery of Function (日) (読) [継承]
20. (英) Serum Albumin (日) (読) [継承]
21. (英) Weight Loss (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Esophagus (日本食道学会)
(pISSN: 1612-9059, eISSN: 1612-9067)

ISSN (任意): 1612-9067
ISSN: 1612-9059 (pISSN: 1612-9059, eISSN: 1612-9067)
Title: Esophagus : official journal of the Japan Esophageal Society
Title(ISO): Esophagus
Publisher: Springer Japan
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 75 82 [継承]
都市 (任意):
年月日 (必須): 西暦 2018年 4月 初日 (平成 30年 4月 初日) [継承]
URL (任意):
DOI (任意): 10.1007/s10388-017-0601-9    (→Scopusで検索) [継承]
PMID (任意): 29892933    (→Scopusで検索) [継承]
NAID (任意): 40021525944 [継承]
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Scopus (任意): 2-s2.0-85038619573 [継承]
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備考 (任意): 1.(英)   (日) 「国際会議」として同タイトルの別データ有り EID=346303   [継承]
2.(英) Article.ELocationID: 10.1007/s10388-017-0601-9  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Randomized Controlled Trial  (日)    [継承]
5.(英) KeywordList.Keyword: Adrenomedullin  (日)    [継承]
6.(英) KeywordList.Keyword: Daikenchuto  (日)    [継承]
7.(英) KeywordList.Keyword: Esophageal cancer  (日)    [継承]
8.(英) KeywordList.Keyword: Esophagectomy  (日)    [継承]
9.(英) KeywordList.Keyword: TJ-100  (日)    [継承]

標準的な表示

和文冊子 ● Takeshi Nishino, Takahiro Yoshida, Masakazu Goto, Seiya Inoue, Takuya Minato, Satoshi Fujiwara, Yota Yamamoto, Yoshihito Furukita, Yasuhiro Yuasa, Hiromichi Yamai, Hirokazu Takechi, Hiroaki Toba, Hiromitsu Takizawa, Mitsuteru Yoshida, Jun-ichi Seike, Takanori Miyoshi and Akira Tangoku : The effects of the herbal medicine Daikenchuto (TJ-100) after esophageal cancer resection, open-label, randomized controlled trial, Esophagus, Vol.15, No.2, 75-82, 2018.
欧文冊子 ● Takeshi Nishino, Takahiro Yoshida, Masakazu Goto, Seiya Inoue, Takuya Minato, Satoshi Fujiwara, Yota Yamamoto, Yoshihito Furukita, Yasuhiro Yuasa, Hiromichi Yamai, Hirokazu Takechi, Hiroaki Toba, Hiromitsu Takizawa, Mitsuteru Yoshida, Jun-ichi Seike, Takanori Miyoshi and Akira Tangoku : The effects of the herbal medicine Daikenchuto (TJ-100) after esophageal cancer resection, open-label, randomized controlled trial, Esophagus, Vol.15, No.2, 75-82, 2018.

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