『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=348392EID:348392, Map:0, LastModified:2019年3月5日(火) 10:53:32, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[細川 義隆], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1.細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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2.細川 育子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学])
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3.尾崎 和美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学]/[徳島大学.歯学部.口腔保健学科.口腔保健支援学講座])
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4.松尾 敬志
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題名 (必須): (英) Transforming growth factor-β1 increases C-C chemokine ligand 11 production in interleukin 4-stimulated human periodontal ligament cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Transforming growth factor (TGF)-β1 is a multifunctional cytokine, which can control certain functions of various kinds of cells. However, it is unclear whether TGF-β1 affects T-cell migration in periodontal lesions. The aim of this study was to examine the effects of TGF-β1 on the production of C-C chemokine ligand (CCL)11, which is a T-helper 2-type chemokine, in human periodontal ligament cells (HPDLC). Interleukin (IL)-4 induced CCL11 production, but TGF-β1 did not, in HPDLC. However, TGF-β1 enhanced CCL11 production in IL-4-stimulated HPDLC. Western blot analysis showed that the signal transducer and activator of transcription 6 (STAT6) pathway was highly activated in HPDLC that had been stimulated with both IL-4 and TGF-β1. Mitogen-activated protein kinase activation did not differ between the HPDLC treated with a combination of IL-4 and TGF-β1 and those treated with IL-4 or TGF-β1 alone. Moreover, a STAT6 inhibitor significantly inhibited CCL11 production in HPDLC that had been stimulated with IL-4 and TGF-β1. The current study clearly demonstrated that TGF-β1 enhanced IL-4-induced CCL11 production in HPDLC. The STAT6 pathway is important for CCL11 production in IL-4- and TGF-β1-treated HPDLC.  (日)    [継承]
キーワード (推奨): 1. (英) Cells, Cultured (日) (読) [継承]
2. (英) Chemokine CCL11 (日) (読) [継承]
3. (英) Chemokines, CC (日) (読) [継承]
4.細胞質分裂 (cytokinesis) [継承]
5. (英) Humans (日) (読) [継承]
6. (英) Interleukin-4 (日) (読) [継承]
7. (英) Periodontal Ligament (日) (読) [継承]
8.リン酸化 (phosphorylation) [継承]
9. (英) STAT6 Transcription Factor (日) (読) [継承]
10.シグナル伝達 (signal transduction) [継承]
11. (英) Transforming Growth Factor beta1 (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Cell Biology International (International Federation for Cell Biology)
(pISSN: 1065-6995, eISSN: 1095-8355)

ISSN (任意): 1095-8355
ISSN: 1065-6995 (pISSN: 1065-6995, eISSN: 1095-8355)
Title: Cell biology international
Title(ISO): Cell Biol Int
Supplier: International Federation for Cell Biology
Publisher: Blackwell
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 42 [継承]
(必須): 10 [継承]
(必須): 1395 1400 [継承]
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年月日 (必須): 西暦 2018年 7月 24日 (平成 30年 7月 24日) [継承]
URL (任意):
DOI (任意): 10.1002/cbin.11030    (→Scopusで検索) [継承]
PMID (任意): 29993161    (→Scopusで検索) [継承]
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機関リポジトリ : 112813 [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki and Takashi Matsuo : Transforming growth factor-β1 increases C-C chemokine ligand 11 production in interleukin 4-stimulated human periodontal ligament cells., Cell Biology International, Vol.42, No.10, 1395-1400, 2018.
欧文冊子 ● Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki and Takashi Matsuo : Transforming growth factor-β1 increases C-C chemokine ligand 11 production in interleukin 4-stimulated human periodontal ligament cells., Cell Biology International, Vol.42, No.10, 1395-1400, 2018.

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