| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
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| ○著者 (必須): | 1. | 細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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| 2. | 細川 育子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.⻭科保存学])
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| 3. | 尾崎 和美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学]/[徳島大学.歯学部.口腔保健学科.口腔保健支援学講座])
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| 4. | 松尾 敬志
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| ○題名 (必須): | □ | (英) Transforming growth factor-β1 increases C-C chemokine ligand 11 production in interleukin 4-stimulated human periodontal ligament cells. (日)
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| ○要約 (任意): | □ | (英) Transforming growth factor (TGF)-β1 is a multifunctional cytokine, which can control certain functions of various kinds of cells. However, it is unclear whether TGF-β1 affects T-cell migration in periodontal lesions. The aim of this study was to examine the effects of TGF-β1 on the production of C-C chemokine ligand (CCL)11, which is a T-helper 2-type chemokine, in human periodontal ligament cells (HPDLC). Interleukin (IL)-4 induced CCL11 production, but TGF-β1 did not, in HPDLC. However, TGF-β1 enhanced CCL11 production in IL-4-stimulated HPDLC. Western blot analysis showed that the signal transducer and activator of transcription 6 (STAT6) pathway was highly activated in HPDLC that had been stimulated with both IL-4 and TGF-β1. Mitogen-activated protein kinase activation did not differ between the HPDLC treated with a combination of IL-4 and TGF-β1 and those treated with IL-4 or TGF-β1 alone. Moreover, a STAT6 inhibitor significantly inhibited CCL11 production in HPDLC that had been stimulated with IL-4 and TGF-β1. The current study clearly demonstrated that TGF-β1 enhanced IL-4-induced CCL11 production in HPDLC. The STAT6 pathway is important for CCL11 production in IL-4- and TGF-β1-treated HPDLC. (日)
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| ○キーワード (推奨): | 1. | (英) Cells, Cultured (日) (読)
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| 2. | (英) Chemokine CCL11 (日) (読)
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| 3. | (英) Chemokines, CC (日) (読)
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| 4. | 細胞質分裂 (cytokinesis)
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| 5. | (英) Humans (日) (読)
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| 6. | (英) Interleukin-4 (日) (読)
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| 7. | (英) Periodontal Ligament (日) (読)
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| 8. | リン酸化 (phosphorylation)
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| 9. | (英) STAT6 Transcription Factor (日) (読)
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| 10. | シグナル伝達 (signal transduction)
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| 11. | (英) Transforming Growth Factor beta1 (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Cell Biology International (International Federation for Cell Biology)
(pISSN: 1065-6995, eISSN: 1095-8355)
| ○ISSN (任意): | □ | 1095-8355
ISSN: 1065-6995
(pISSN: 1065-6995, eISSN: 1095-8355) Title: Cell biology internationalTitle(ISO): Cell Biol IntSupplier: International Federation for Cell BiologyPublisher: Blackwell (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 42
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| ○号 (必須): | □ | 10
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| ○頁 (必須): | □ | 1395 1400
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2018年 7月 24日 (平成 30年 7月 24日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1002/cbin.11030 (→Scopusで検索)
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| ○PMID (任意): | □ | 29993161 (→Scopusで検索)
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| ○機関リポジトリ : | □ | 112813
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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