| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Watanabe-Kamiyama Mari (日) (読)
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| 2. | (英) Shimizu Muneshige (日) (読)
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| 3. | (英) Kamiyama Shin (日) (読)
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| 4. | (英) Taguchi Yasuki (日) (読)
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| 5. | (英) Sone Hideyuki (日) (読)
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| 6. | 森松 文毅 ([徳島大学.研究支援・産官学連携センター])
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| 7. | (英) Shirakawa Hitoshi (日) (読)
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| 8. | (英) Furukawa Yuji (日) (読)
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| 9. | (英) Komai Michio (日) (読)
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| ○題名 (必須): | □ | (英) Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Collagen, a major extracellular matrix macromolecule, is widely used for biomedical purposes. We investigated the absorption mechanism of low molecular weight collagen hydrolysate (LMW-CH) and its effects on osteoporosis in rats. When administered to Wistar rats with either [(14)C]proline (Pro group) or glycyl-[(14)C]prolyl-hydroxyproline (CTp group), LMW-CH rapidly increased plasma radioactivity. LMW-CH was absorbed into the blood of Wistar rats in the peptide form. Glycyl-prolyl-hydroxyproline tripeptide remained in the plasma and accumulated in the kidney. In both groups, radioactivity was retained at a high level in the skin until 14 days after administration. Additionally, the administration of LMW-CH to ovariectomized stroke-prone spontaneously hypertensive rats increased the organic substance content and decreased the water content of the left femur. Our findings show that LMW-CH exerts a beneficial effect on osteoporosis by increasing the organic substance content of bone. (日)
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| ○キーワード (推奨): | 1. | (英) Absorption (日) (読)
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| 2. | (英) Administration, Oral (日) (読)
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| 3. | (英) Animals (日) (読)
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| 4. | (英) Chickens (日) (読)
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| 5. | コラーゲン (collagen)
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| 6. | (英) Disease Models, Animal (日) (読)
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| 7. | (英) Female (日) (読)
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| 8. | (英) Femur (日) (読)
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| 9. | (英) Humans (日) (読)
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| 10. | 分子量 (molecular weight)
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| 11. | (英) Osteoporosis (日) (読)
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| 12. | (英) Ovariectomy (日) (読)
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| 13. | (英) Protein Hydrolysates (日) (読)
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| 14. | (英) Random Allocation (日) (読)
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| 15. | (英) Rats (日) (読)
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| 16. | (英) Rats, Wistar (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Agricultural and Food Chemistry ([アメリカ化学会])
(pISSN: 0021-8561, eISSN: 1520-5118)
| ○ISSN (任意): | □ | 1520-5118
ISSN: 0021-8561
(pISSN: 0021-8561, eISSN: 1520-5118) Title: Journal of agricultural and food chemistryTitle(ISO): J Agric Food ChemPublisher: American Chemical Society (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 58
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 835 841
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2010年 10月 初日 (平成 22年 10月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1021/jf9031487 (→Scopusで検索)
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| ○PMID (任意): | □ | 19957932 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-74849132803
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| ○researchmap (任意): |
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1021/jf9031487 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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