| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Zhang Youzuo (日) (読)
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| 2. | (英) Kouguchi Tomomi (日) (読)
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| 3. | (英) Shimizu Muneshige (日) (読)
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| 4. | (英) Ohmori Takashi (日) (読)
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| 5. | (英) Takahata Yoshihisa (日) (読)
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| 6. | 森松 文毅 ([徳島大学.研究支援・産官学連携センター])
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| ○題名 (必須): | □ | (英) Chicken collagen hydrolysate protects rats from hypertension and cardiovascular damage. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) We previously reported that chicken collagen hydrolysate (CCH) has strong angiotensin I converting enzyme (ACE) inhibitory activity and antihypertensive effects on spontaneously hypertensive rats. Here, we investigated the chronic therapy effects of CCH on blood pressure and vascular relaxation in a cardiovascular damage model of Wistar-Kyoto rats induced by N-nitro-l-arginine methyl ester (L-NAME). Following co-treatment with CCH for 4 weeks, the increment of systolic blood pressure was suppressed significantly. At 8 weeks, the vasorelaxation of thoracic aorta increased significantly, and cardiovascular damage was ameliorated. The concentration of soluble intercellular adhesion molecule-1 (ICAM-1) in blood was reduced significantly by long-term administration of CCH, whereas the nitric oxide concentration was increased significantly at 1 hour post-treatment. The results suggest that beneficial effects of CCH result from antihypertensive function, but also from inhibition of cardiovascular damage to the endothelial cells via its ACE inhibitory activity and regulation of nitric oxide and ICAM-1, which suggests that CCH may be useful as a medicinal food for patients with cardiovascular disease. (日)
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| ○キーワード (推奨): | 1. | (英) Angiotensin-Converting Enzyme Inhibitors (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Antihypertensive Agents (日) (読)
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| 4. | (英) Aorta (日) (読)
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| 5. | 血圧 (blood pressure)
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| 6. | (英) Chickens (日) (読)
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| 7. | コラーゲン (collagen)
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| 8. | (英) Endothelial Cells (日) (読)
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| 9. | (英) Endothelium, Vascular (日) (読)
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| 10. | (英) Hydrolysis (日) (読)
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| 11. | 高血圧 (hypertension)
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| 12. | (英) Intercellular Adhesion Molecule-1 (日) (読)
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| 13. | (英) Male (日) (読)
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| 14. | 一酸化窒素 (nitric oxide)
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| 15. | (英) Rats (日) (読)
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| 16. | (英) Rats, Inbred WKY (日) (読)
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| 17. | (英) Vascular Diseases (日) (読)
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| 18. | (英) Vasodilation (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Medicinal Food (Mary Ann Liebert, Inc.)
(pISSN: 1096-620X, eISSN: 1557-7600)
| ○ISSN (任意): | □ | 1557-7600
ISSN: 1096-620X
(pISSN: 1096-620X, eISSN: 1557-7600) Title: Journal of medicinal foodTitle(ISO): J Med FoodPublisher: Mary Ann Liebert Inc. (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 13
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 399 405
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2010年 4月 初日 (平成 22年 4月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1089/jmf.2009.1246 (→Scopusで検索)
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| ○PMID (任意): | □ | 20170381 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-77957735285
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1089/jmf.2009.1246 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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