| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Saiga Ai (日) (読)
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| 2. | (英) Iwai Koji (日) (読)
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| 3. | (英) Hayakawa Toru (日) (読)
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| 4. | (英) Takahata Yoshihisa (日) (読)
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| 5. | (英) Kitamura Shiniich (日) (読)
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| 6. | (英) Nishimura Toshihide (日) (読)
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| 7. | 森松 文毅 ([徳島大学.研究支援・産官学連携センター])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Angiotensin I-converting enzyme-inhibitory peptides obtained from chicken collagen hydrolysate. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) In this study, collagen extracted from chicken legs (which are the yellow keratin parts containing a nail) was hydrolyzed with various enzymes, and the angiotensin I-converting enzyme (ACE)-inhibitory activity of each hydrolysate was determined. The hydrolysate by treatment with an Aspergillus species-derived enzyme had the highest activity (IC 50 = 260 microg/mL). The fraction of this hydrolysate obtained by ultrafiltration with a molecular-weight cutoff of 3000 Da (low fraction) had a stronger activity (IC 50 = 130 microg/mL) than the fractionated one. This fraction was further fractionated by HPLC, and the peptides in the fraction with high ACE-inhibitory activity were identified. The amino acid sequences of the four peptides were identified using a protein sequencer. These peptides were synthesized to confirm their ACE-inhibitory activities; this showed that peptides with a Gly-Ala-Hyp-Gly-Leu-Hyp-Gly-Pro sequence had the highest activity (IC 50 = 29 microM). When the low fraction was administered to spontaneous hypertensive rats, a decrease in their blood pressure was observed after 2 h of administration, and a significant decrease in blood pressure (-50 mmHg) was observed after 6 h. Moreover, long-term administration studies indicated that the low fraction showed a significant suppression of increased blood pressure. (日)
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| ○キーワード (推奨): | 1. | (英) Angiotensin-Converting Enzyme Inhibitors (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Antihypertensive Agents (日) (読)
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| 4. | 血圧 (blood pressure)
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| 5. | (英) Chickens (日) (読)
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| 6. | コラーゲン (collagen)
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| 7. | (英) Male (日) (読)
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| 8. | 質量分析法 (mass spectrometry)
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| 9. | (英) Peptides (日) (読)
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| 10. | (英) Peptidyl-Dipeptidase A (日) (読)
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| 11. | (英) Protein Hydrolysates (日) (読)
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| 12. | (英) Rabbits (日) (読)
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| 13. | (英) Rats (日) (読)
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| 14. | (英) Rats, Inbred SHR (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Agricultural and Food Chemistry ([アメリカ化学会])
(pISSN: 0021-8561, eISSN: 1520-5118)
| ○ISSN (任意): | □ | 1520-5118
ISSN: 0021-8561
(pISSN: 0021-8561, eISSN: 1520-5118) Title: Journal of agricultural and food chemistryTitle(ISO): J Agric Food ChemPublisher: American Chemical Society (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 56
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| ○号 (必須): | □ | 20
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| ○頁 (必須): | □ | 9586 9591
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2008年 3月 初日 (平成 20年 3月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1021/jf072669w (→Scopusで検索)
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| ○PMID (任意): | □ | 18808143 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-55549138780
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1021/jf072669w (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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