『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=344468)

EID=344468EID:344468, Map:0, LastModified:2020年9月2日(水) 19:06:42, Operator:[橋本 登], Avail:TRUE, Censor:0, Owner:[橋本 登], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Furukawa Koichi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Ohmi Yuhsuke (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Ji Shuting (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Zhang Pu (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Bhuiyan H. Robiul (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Ohkawa Yuki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Tajima Orie (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
8.橋本 登 ([徳島大学.大学院医歯薬学研究部.歯学域.先端歯学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.組織再生制御学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
9. (英) Furukawa Keiko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Glycolipids: Essential regulator of neuro-inflammation, metabolism and gliomagenesis.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Gene knockout mice of glycosyltransferases have clearly showed roles of their products in the bodies, while there are examples where phenotype of knockout was much less severe than expected probably due to functional redundancy. The most striking novel finding obtained from ganglioside-deficient mice was that progressive inflammatory reaction took place, leading to neurodegeneration. In particular, dysfunction of complement-regulatory proteins due to deteriorated architecture of lipid rafts seemed to be essential mechanisms for the inflammation. Furthermore, roles of gangliosides in neurons were demonstrated by neuron-specific transgenic of B4galnt1 with genetic background of B4galnt1 deficiency. From study of gene knockout mice of St8sia1, new roles of b-series gangliosides in leptin secretion from adipocytes, and roles of a-series gangliosides in leptin receptor, ObR in hypothalamus were demonstrated, leading to apparent intact balance of energy. Essential roles of b-series gangliosides in malignant properties of gliomas were also shown, suggesting their roles in the regulation of inflammation and proliferation in nervous tissues. How to apply these findings for the control of newly discovered patients with ganglioside deficiency remains to be investigated. This article is part of a Special Issue entitled Neuro-glycoscience, edited by Kenji Kadomatsu and Hiroshi Kitagawa.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Complement System Proteins (日) (読) [継承]
3. (英) Gangliosides (日) (読) [継承]
4. (英) Gene Expression Regulation, Neoplastic (日) (読) [継承]
5. (英) Glioma (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Inflammation (日) (読) [継承]
8. (英) Leptin (日) (読) [継承]
9. (英) Membrane Microdomains (日) (読) [継承]
10. (英) Mice (日) (読) [継承]
11. (英) Mice, Knockout (日) (読) [継承]
12. (英) N-Acetylgalactosaminyltransferases (日) (読) [継承]
13. (英) Neoplasms, Nerve Tissue (日) (読) [継承]
14. (英) Nerve Tissue (日) (読) [継承]
15. (英) Neurons (日) (読) [継承]
16. (英) Receptors, Leptin (日) (読) [継承]
17. (英) Sialyltransferases (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Biochimica et Biophysica Acta (BBA) - General Subjects ([Elsevier Science])
(pISSN: 0304-4165, eISSN: 1872-8006)

ISSN (任意): 0304-4165
ISSN: 0304-4165 (pISSN: 0304-4165, eISSN: 1872-8006)
Title: Biochimica et biophysica acta. General subjects
Title(ISO): Biochim Biophys Acta Gen Subj
Publisher: Elsevier B.V.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 1861 [継承]
(必須): 10 [継承]
(必須): 2479 2484 [継承]
都市 (任意):
年月日 (必須): 西暦 2017年 6月 7日 (平成 29年 6月 7日) [継承]
URL (任意):
DOI (任意): 10.1016/j.bbagen.2017.06.007    (→Scopusで検索) [継承]
PMID (任意): 28602513    (→Scopusで検索) [継承]
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Scopus (任意):
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備考 (任意): 1.(英) Article.ELocationID: S0304-4165(17)30193-9  (日)    [継承]
2.(英) Article.ELocationID: 10.1016/j.bbagen.2017.06.007  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Review  (日)    [継承]
5.(英) KeywordList.Keyword: Astrocyte  (日)    [継承]
6.(英) KeywordList.Keyword: Complement  (日)    [継承]
7.(英) KeywordList.Keyword: Ganglioside  (日)    [継承]
8.(英) KeywordList.Keyword: Glioma  (日)    [継承]
9.(英) KeywordList.Keyword: Inflammation  (日)    [継承]
10.(英) KeywordList.Keyword: Knockout  (日)    [継承]
11.(英) KeywordList.Keyword: Neurodegeneration  (日)    [継承]

標準的な表示

和文冊子 ● Koichi Furukawa, Yuhsuke Ohmi, Shuting Ji, Pu Zhang, Robiul H. Bhuiyan, Yuki Ohkawa, Orie Tajima, Noboru Hashimoto and Keiko Furukawa : Glycolipids: Essential regulator of neuro-inflammation, metabolism and gliomagenesis., Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1861, No.10, 2479-2484, 2017.
欧文冊子 ● Koichi Furukawa, Yuhsuke Ohmi, Shuting Ji, Pu Zhang, Robiul H. Bhuiyan, Yuki Ohkawa, Orie Tajima, Noboru Hashimoto and Keiko Furukawa : Glycolipids: Essential regulator of neuro-inflammation, metabolism and gliomagenesis., Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1861, No.10, 2479-2484, 2017.

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