『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=344187EID:344187, Map:0, LastModified:2021年1月5日(火) 16:46:03, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[中川 貴之], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Ohta K (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Naruse T (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Ishida Y (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Shigeishi H (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.中川 貴之
役割 (任意):
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学籍番号 (推奨):
[継承]
6. (英) Fukui A (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Nishi H (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Sasaki K (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
9. (英) Ogawa I (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
10. (英) Takechi M (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) TNF- -induced IL-6 and MMP-9 expression in immortalized ameloblastoma cell line established by hTERT.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Ameloblastoma (AM) shows locally invasive behaviour. However, biological investigations regarding regulation of gene expression associated with AM pathological features are difficult to perform, because AM cells can be passaged for a few generations due to senescence. We report a newly established immortalized AM cell line, AMB cells, by transfection with human telomerase reverse transcriptase (hTERT). Furthermore, we examined whether TNF- modulates bone resorption-related genes, IL-6 and MMP-9 in cooperation with TGF- or IFN- . Following transfection of an hTERT expression vector into AM cells using a non-viral method, the effects of cytokines on the expressions of IL-6 and MMP-9 mRNA were examined using real-time PCR. TNF- -induced NF- B activity was examined by western blotting and transcription factor assays. AMB cells continued to grow for more than 100 population doublings. Stimulation with TNF- increased IL-6 and MMP-9 mRNA expressions, as well as NF- B activation. Furthermore, TGF- and IFN- dramatically increased TNF- -mediated expressions of MMP-9 and IL-6 mRNA, respectively, while those responses were suppressed by NF- B inhibitor. We established an immortalized AM cell line by hTERT transfection. TNF- -mediated regulation of MMP-9 and IL-6 via NF- B may play an important role in the pathological behaviour of AMs, such as bone resorption.  (日)    [継承]
キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Ameloblastoma (日) (読) [継承]
3. (英) Cell Line, Tumor (日) (読) [継承]
4. (英) Cell Proliferation (日) (読) [継承]
5. (英) Cellular Senescence (日) (読) [継承]
6.女性 (female) [継承]
7.遺伝子発現 (gene expression) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Interferon-gamma (日) (読) [継承]
10. (英) Interleukin-6 (日) (読) [継承]
11. (英) Jaw Neoplasms (日) (読) [継承]
12. (英) Matrix Metalloproteinase 9 (日) (読) [継承]
13. (英) NF-kappa B (日) (読) [継承]
14. (英) Nitriles (日) (読) [継承]
15. (英) RNA, Messenger (日) (読) [継承]
16. (英) Sulfones (日) (読) [継承]
17. (英) Telomerase (日) (読) [継承]
18. (英) Transfection (日) (読) [継承]
19. (英) Transforming Growth Factor beta (日) (読) [継承]
20. (英) Tumor Necrosis Factor-alpha (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Oral Diseases (Munksgaard)
(pISSN: 1354-523X, eISSN: 1601-0825)

ISSN (任意): 1601-0825
ISSN: 1354-523X (pISSN: 1354-523X, eISSN: 1601-0825)
Title: Oral diseases
Title(ISO): Oral Dis
Publisher: Blackwell
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 23 [継承]
(必須): 2 [継承]
(必須): 199 209 [継承]
都市 (任意):
年月日 (必須): 西暦 2016年 11月 21日 (平成 28年 11月 21日) [継承]
URL (任意):
DOI (任意): 10.1111/odi.12594    (→Scopusで検索) [継承]
PMID (任意): 27868311    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1111/odi.12594  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) KeywordList.Keyword: IL-6  (日)    [継承]
4.(英) KeywordList.Keyword: MMP-9  (日)    [継承]
5.(英) KeywordList.Keyword: TNF-  (日)    [継承]
6.(英) KeywordList.Keyword: ameloblastoma  (日)    [継承]
7.(英) KeywordList.Keyword: human telomerase reverse transcriptase  (日)    [継承]

標準的な表示

和文冊子 ● K Ohta, T Naruse, Y Ishida, H Shigeishi, Takayuki Nakagawa, A Fukui, H Nishi, K Sasaki, I Ogawa and M Takechi : TNF- -induced IL-6 and MMP-9 expression in immortalized ameloblastoma cell line established by hTERT., Oral Diseases, Vol.23, No.2, 199-209, 2016.
欧文冊子 ● K Ohta, T Naruse, Y Ishida, H Shigeishi, Takayuki Nakagawa, A Fukui, H Nishi, K Sasaki, I Ogawa and M Takechi : TNF- -induced IL-6 and MMP-9 expression in immortalized ameloblastoma cell line established by hTERT., Oral Diseases, Vol.23, No.2, 199-209, 2016.

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