『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=343891EID:343891, Map:0, LastModified:2018年9月21日(金) 15:51:15, Operator:[三好 小文], Avail:TRUE, Censor:0, Owner:[金子 一郎], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨): 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) [継承]
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著者 (必須): 1.金子 一郎 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.応用栄養学])
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2.瀬川 博子 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.応用栄養学])
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3. (英) Kayo Ikuta (日) (読)
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4. (英) Ai Hanazaki (日) (読)
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5. (英) Toru Fujii (日) (読)
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6.辰巳 佐和子
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7. (英) Shinsuke Kido (日) (読)
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8. (英) Tomoka Hasegawa (日) (読)
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9. (英) Norio Amizuka (日) (読)
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10. (英) Hitoshi Saito (日) (読)
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11.宮本 賢一
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題名 (必須): (英) Eldecalcitol Causes FGF23 Resistance for Pi Reabsorption and Improves Rachitic Bone Phenotypes in the Male Hyp Mouse.  (日)    [継承]
副題 (任意):
要約 (任意): (英) X-linked hypophosphatemia (XLH), the most common form of inheritable rickets, is caused by inactivation of phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX) and leads to fibroblast growth factor (FGF) 23-dependent renal inorganic phosphate (Pi) wasting. In the present study, we investigated whether maintaining Pi homeostasis with a potent vitamin D3 analog, eldecalcitol [1α,25-dihydroxy-2β-(3-hydroxypropyloxy) vitamin D3; ED71], could improve hypophosphatemic rickets in a murine model of XLH, the Hyp mouse. Vehicle, ED71, or 1,25-dihydroxyvitamin D was subcutaneously injected five times weekly in wild-type (WT) and Hyp mice for 4 weeks, from 4 to 8 weeks of age. Injection of ED71 into WT mice suppressed the synthesis of renal 1,25-dihydroxyvitamin D and promoted phosphaturic activity. In contrast, administration of ED71 to Hyp mice completely restored renal Pi transport and NaPi-2a protein levels, although the plasma-intact FGF23 levels were further increased. In addition, ED71 markedly increased the levels of the scaffold proteins, renal sodium-hydrogen exchanger regulatory factor 1, and ezrin in the Hyp mouse kidney. Treatment with ED71 increased the body weight and improved hypophosphatemia, the bone volume/total volume, bone mineral content, and growth plate structure in Hyp mice. Thus, ED71 causes FGF23 resistance for phosphate reabsorption and improves rachitic bone phenotypes in Hyp mice. In conclusion, ED71 has opposite effects on phosphate homeostasis in WT and Hyp mice. Analysis of Hyp mice treated with ED71 could result in an additional model for elucidating PHEX abnormalities.  (日)    [継承]
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誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 1945-7170
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 2741 2758 [継承]
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年月日 (必須): 西暦 2018年 7月 1日 (平成 30年 7月 1日) [継承]
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DOI (任意): 10.1210/en.2018-00109    (→Scopusで検索) [継承]
PMID (任意): 29878089    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1210/en.2018-00109  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Ichiro Kaneko, Hiroko Segawa, Ikuta Kayo, Hanazaki Ai, Fujii Toru, Sawako Tatsumi, Kido Shinsuke, Hasegawa Tomoka, Amizuka Norio, Saito Hitoshi and Ken-ichi Miyamoto : Eldecalcitol Causes FGF23 Resistance for Pi Reabsorption and Improves Rachitic Bone Phenotypes in the Male Hyp Mouse., Endocrinology, Vol.159, No.7, 2741-2758, 2018.
欧文冊子 ● Ichiro Kaneko, Hiroko Segawa, Ikuta Kayo, Hanazaki Ai, Fujii Toru, Sawako Tatsumi, Kido Shinsuke, Hasegawa Tomoka, Amizuka Norio, Saito Hitoshi and Ken-ichi Miyamoto : Eldecalcitol Causes FGF23 Resistance for Pi Reabsorption and Improves Rachitic Bone Phenotypes in the Male Hyp Mouse., Endocrinology, Vol.159, No.7, 2741-2758, 2018.

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