『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=343699EID:343699, Map:0, LastModified:2018年11月29日(木) 11:56:58, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[友成 さゆり], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Kato Mutsuko (日) (読)
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[継承]
2. (英) Sugiyama Takashi (日) (読)
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[継承]
3. (英) Sakai Kazumi (日) (読)
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[継承]
4. (英) Yamashita Takahiro (日) (読)
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[継承]
5. (英) Fujita Hirofumi (日) (読)
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[継承]
6. (英) Sato Keita (日) (読)
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7.友成 さゆり ([徳島大学.技術支援部.常三島技術部門])
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[継承]
8. (英) Shichida Yoshinori (日) (読)
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[継承]
9. (英) Ohuchi Hideyo (日) (読)
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[継承]
題名 (必須): (英) Two Opsin 3-Related Proteins in the Chicken Retina and Brain: A TMT-Type Opsin 3 Is a Blue-Light Sensor in Retinal Horizontal Cells, Hypothalamus, and Cerebellum.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Opsin family genes encode G protein-coupled seven-transmembrane proteins that bind a retinaldehyde chromophore in photoreception. Here, we sought potential as yet undescribed avian retinal photoreceptors, focusing on Opsin 3 homologs in the chicken. We found two Opsin 3-related genes in the chicken genome: one corresponding to encephalopsin/panopsin (Opn3) in mammals, and the other belonging to the teleost multiple tissue opsin (TMT) 2 group. Bioluminescence imaging and G protein activation assays demonstrated that the chicken TMT opsin (cTMT) functions as a blue light sensor when forced-expressed in mammalian cultured cells. We did not detect evidence of light sensitivity for the chicken Opn3 (cOpn3). In situ hybridization demonstrated expression of cTMT in subsets of differentiating cells in the inner retina and, as development progressed, predominant localization to retinal horizontal cells (HCs). Immunohistochemistry (IHC) revealed cTMT in HCs as well as in small numbers of cells in the ganglion and inner nuclear layers of the post-hatch chicken retina. In contrast, cOpn3-IR cells were found in distinct subsets of cells in the inner nuclear layer. cTMT-IR cells were also found in subsets of cells in the hypothalamus. Finally, we found differential distribution of cOpn3 and cTMT proteins in specific cells of the cerebellum. The present results suggest that a novel TMT-type opsin 3 may function as a photoreceptor in the chicken retina and brain.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (brain) [継承]
3.カルシウム (calcium) [継承]
4.小脳 (cerebellum) [継承]
5. (英) Chickens (日) (読) [継承]
6. (英) Exons (日) (読) [継承]
7.遺伝子発現 (gene expression) [継承]
8. (英) Genomics (日) (読) [継承]
9.視床下部 (hypothalamus) [継承]
10. (英) Introns (日) (読) [継承]
11. (英) Light (日) (読) [継承]
12. (英) Multigene Family (日) (読) [継承]
13. (英) Phylogeny (日) (読) [継承]
14. (英) Protein Transport (日) (読) [継承]
15. (英) RNA Transport (日) (読) [継承]
16. (英) RNA, Messenger (日) (読) [継承]
17.網膜 (retina) [継承]
18. (英) Retinal Horizontal Cells (日) (読) [継承]
19. (英) Rod Opsins (日) (読) [継承]
発行所 (推奨):
誌名 (必須): PLoS ONE (Public Library of Science)
(eISSN: 1932-6203)

ISSN (任意): 1932-6203
ISSN: 1932-6203 (eISSN: 1932-6203)
Title: PloS one
Title(ISO): PLoS One
Publisher: PLOS
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 11 [継承]
(必須): 11 [継承]
(必須): e0163925 e0163925 [継承]
都市 (任意):
年月日 (必須): 西暦 2016年 11月 18日 (平成 28年 11月 18日) [継承]
URL (任意):
DOI (任意): 10.1371/journal.pone.0163925    (→Scopusで検索) [継承]
PMID (任意): 27861495    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-84995545985 [継承]
機関リポジトリ : 112362 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1371/journal.pone.0163925  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) CoiStatement: Olympus Corporation: this commercial affiliation does not alter our adherence to all PLOS ONE policies on sharing data and materials. Pfizer Japan Inc.: this commercial funder does not alter our adherence to PLOS ONE policies on sharing data and materials, either.  (日)    [継承]

標準的な表示

和文冊子 ● Mutsuko Kato, Takashi Sugiyama, Kazumi Sakai, Takahiro Yamashita, Hirofumi Fujita, Keita Sato, Sayuri Tomonari, Yoshinori Shichida and Hideyo Ohuchi : Two Opsin 3-Related Proteins in the Chicken Retina and Brain: A TMT-Type Opsin 3 Is a Blue-Light Sensor in Retinal Horizontal Cells, Hypothalamus, and Cerebellum., PLoS ONE, Vol.11, No.11, e0163925, 2016.
欧文冊子 ● Mutsuko Kato, Takashi Sugiyama, Kazumi Sakai, Takahiro Yamashita, Hirofumi Fujita, Keita Sato, Sayuri Tomonari, Yoshinori Shichida and Hideyo Ohuchi : Two Opsin 3-Related Proteins in the Chicken Retina and Brain: A TMT-Type Opsin 3 Is a Blue-Light Sensor in Retinal Horizontal Cells, Hypothalamus, and Cerebellum., PLoS ONE, Vol.11, No.11, e0163925, 2016.

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