| ○種別 (必須): | □ | 総説·解説
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): | □ | 依頼
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| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 学内共著 (徳島大学内研究者との共同研究 (学外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 湯本 浩通 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯周歯内治療学])
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| 2. | 平尾 功治
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| 3. | 細川 由樹 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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| 4. | 蔵本 瞳 ([徳島大学.大学院医歯薬学研究部.歯学域.先端歯学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.小児歯科学])
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| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 5. | 武川 大輔 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.⻭科保存学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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| 6. | 中西 正 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.⻭科保存学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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| 7. | 松尾 敬志
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| ○題名 (必須): | □ | (英) The Roles of Odontoblasts in Dental Pulp Innate Immunity (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Odontoblasts located in the outermost layer of dental pulp form a natural barrier between mineralized tissues, dentin, and soft tissues, dental pulp, of the vital tooth, and they first recognize caries-related pathogens and sense external irritations. Therefore, odontoblasts possess a specialized innate immune system to fight oral pathogens invading into dentin. Generally, the rapid initial sensing of microbial pathogens, especially pathogen-associated molecular patterns (PAMPs) shared by microorganisms, are mediated by pattern recognition receptors (PRRs), such as Toll-like receptor and the nucleotide-binding oligomerization domain (NOD). The innate immune responses in odontoblasts initiated by sensing oral pathogens provide host protective events, such as inflammatory reactions, to produce a variety of pro-inflammatory mediators, including chemokines and cytokines. These attract various inflammatory cells and cause antibacterial reactions, such as the production of defensins, to kill microorganisms in the proximal region of the odontoblast layer. This review focuses on innate immunity, especially cellular and molecular mechanisms regarding the sensing of PAMPs from oral pathogens by PRRs, in odontoblasts and provides information for future studies for the development of novel therapeutic strategies, including diagnosis and treatment, to prevent exceeding dental pulp inflammation and preserve the dental pulp tissues. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Japanese Dental Science Review (日本歯科医学会)
(pISSN: 1882-7616, eISSN: 2213-6851)
| ○ISSN (任意): | □ | 1882-7616
ISSN: 1882-7616
(pISSN: 1882-7616, eISSN: 2213-6851) Title: The Japanese dental science reviewTitle(ISO): Jpn Dent Sci RevPublisher: Elsevier Ltd (NLM Catalog)
(医中誌Web)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 54
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 105 117
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| ○年月日 (必須): | □ | 西暦 2018年 8月 初日 (平成 30年 8月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.jdsr.2018.03.001 (→Scopusで検索)
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| ○PMID (任意): | □ | 30128058 (→Scopusで検索)
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| ○Scopus (任意): | □ | 2-s2.0-85044379499
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| ○機関リポジトリ : | □ | 112960
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.jdsr.2018.03.001 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Review (日)
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| 4. | (英) KeywordList.Keyword: Damage-associated molecular pattern (日)
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| 5. | (英) KeywordList.Keyword: Inflammation (日)
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| 6. | (英) KeywordList.Keyword: Odontoblast (日)
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| 7. | (英) KeywordList.Keyword: Pathogen-associated molecular pattern (日)
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| 8. | (英) KeywordList.Keyword: Pattern recognition receptor (日)
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| 9. | (英) KeywordList.Keyword: Pro-inflammatory mediator (日)
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