『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=343011EID:343011, Map:0, LastModified:2018年8月13日(月) 15:42:21, Operator:[堀ノ内 裕也], Avail:TRUE, Censor:0, Owner:[堀ノ内 裕也], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1. (英) Tsuda Katsunori (日) 津田 勝範 (読) つだ かつのり
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学籍番号 (推奨): **** [ユーザ]
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2.宮本 理人
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3.濱野 修一
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4. (英) Morimoto Yuri (日) (読)
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5. (英) Kangawa Yumi (日) (読)
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6. (英) Fukue Chika (日) (読)
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7. (英) Kagawa Yoko (日) (読)
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8.堀ノ内 裕也
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9. (英) Xu Wenting (日) (読)
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10.池田 康将 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.薬理学]/[徳島大学.医学部.医学科.病態情報医学講座.薬理学分野]/[徳島大学.医科学教育部.医学専攻.病態情報医学講座]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.薬理学])
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11.玉置 俊晃
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12.土屋 浩一郎 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品機能生化学]/[徳島大学.医学部.医学科.病態情報医学講座])
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題名 (必須): (英) Mechanisms of the pH- and Oxygen-Dependent Oxidation Activities of Artesunate.  (日)    [継承]
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要約 (任意): (英) Artemisinin was discovered in 1971 as a constituent of the wormwood genus plant (Artemisia annua). This plant has been used as an herbal medicine to treat malaria since ancient times. The compound artemisinin has a sesquiterpene lactone bearing a peroxide group that offers its biological activity. In addition to anti-malarial activity, artemisinin derivatives have been reported to exert antitumor activity in cancer cells, and have attracted attention as potential anti-cancer drugs. Mechanisms that might explain the antitumor activities of artemisinin derivatives reportedly induction of apoptosis, angiogenesis inhibitory effects, inhibition of hypoxia-inducible factor-1 (HIF-1) activation, and direct DNA injury. Reactive oxygen species (ROS) generation is involved in many cases. However, little is known about the mechanism of ROS formation from artemisinin derivatives and what types of ROS are produced. Therefore, we investigated the iron-induced ROS formation mechanism by using artesunate, a water-soluble artemisinin derivative, which is thought to be the underlying mechanism involved in artesunate-mediated cell death. The ROS generated by the coexistence of iron(II), artesunate, and molecular oxygen was a hydroxyl radical or hydroxyl radical-like ROS. Artesunate can reduce iron(III) to iron(II), which enables generation of ROS irrespective of the iron valence. We found that reduction from iron(III) to iron(II) was activated in the acidic rather than the neutral region and was proportional to the hydrogen ion concentration.  (日)    [継承]
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誌名 (必須): Biological & Pharmaceutical Bulletin ([日本薬学会])
(pISSN: 0918-6158, eISSN: 1347-5215)

ISSN (任意): 1347-5215
ISSN: 0918-6158 (pISSN: 0918-6158, eISSN: 1347-5215)
Title: Biological & pharmaceutical bulletin
Title(ISO): Biol Pharm Bull
Supplier: 公益社団法人日本薬学会
Publisher: Pharmaceutical Society of Japan
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 555 563 [継承]
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年月日 (必須): 西暦 2018年 0月 初日 (平成 30年 0月 初日) [継承]
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DOI (任意): 10.1248/bpb.b17-00855    (→Scopusで検索) [継承]
PMID (任意): 29607928    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Katsunori Tsuda, Licht Miyamoto, Shuichi Hamano, Yuri Morimoto, Yumi Kangawa, Chika Fukue, Yoko Kagawa, Yuya Horinouchi, Wenting Xu, Yasumasa Ikeda, Toshiaki Tamaki and Koichiro Tsuchiya : Mechanisms of the pH- and Oxygen-Dependent Oxidation Activities of Artesunate., Biological & Pharmaceutical Bulletin, Vol.41, No.4, 555-563, 2018.
欧文冊子 ● Katsunori Tsuda, Licht Miyamoto, Shuichi Hamano, Yuri Morimoto, Yumi Kangawa, Chika Fukue, Yoko Kagawa, Yuya Horinouchi, Wenting Xu, Yasumasa Ikeda, Toshiaki Tamaki and Koichiro Tsuchiya : Mechanisms of the pH- and Oxygen-Dependent Oxidation Activities of Artesunate., Biological & Pharmaceutical Bulletin, Vol.41, No.4, 555-563, 2018.

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