| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 十川 悠香 ([徳島大学.病院.診療支援部])
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 福井 誠 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健衛生学])
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| 3. | 中村 信元 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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| 4. | 曽我部 公子 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.内科.血液内科]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.血液・内分泌代謝内科学])
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| 5. | 住谷 龍平 ([徳島大学.病院.診療科.内科.血液内科])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 6. | 吉岡 昌美
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| 7. | 安倍 正博 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.血液・内分泌代謝内科学])
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| 8. | 日野出 大輔 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健衛生学]/[徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座])
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| ○題名 (必須): | □ | (英) Involvement of oral bacteria and oral immunity as risk factors for chemotherapy- induced fever with neutropenia in patients with hematological cancer (日)
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| ○要約 (任意): | □ | (英) The aim of this study is to investigate the association between chemotherapy-induced fever with neutropenia less than 1500/μL (FwN) and oral bacteria and/or oral immunity in patients with hematological cancer. Thirty-two patients with hematological cancer were enrolled in the study. Secretory immunoglobulin A (sIgA) in saliva and the anaerobic bacteria in tongue coating of each subject were assessed before the first chemotherapy. Eleven subjects had an onset of FwN and 21 subjects did not during the observation periods. It was revealed by the Cox-proportional hazard model analysis that the levels of sIgA were low (HR 0.98, p < 0.05) and the rate of Fusobacterium nucleatum [F. nucleatum count per total bacterial count (%)] was high (HR 1.65, p < 0.05) in patients with FwN onset. Using ROC curve analysis, the optimal cutoff point based on the AUC in the F. nucleatum/sIgA ratio was 0.023, and this model had a 78.4% probability (p < 0.01). The risk of FwN onset was also significantly higher among the group of ≥ 0.023 F. nucleatum/sIgA ratio (HR 66.06, p < 0.01). These results suggest that the rate of F. nucleatum and the levels of sIgA at baseline might be related to FwN onset as risk factors. (日)
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| ○キーワード (推奨): | 1. | (英) Adult (日) (読)
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| 2. | (英) Aged (日) (読)
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| 3. | (英) Aged, 80 and over (日) (読)
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| 4. | (英) Antineoplastic Agents (日) (読)
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| 5. | (英) Bacterial Load (日) (読)
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| 6. | (英) Febrile Neutropenia (日) (読)
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| 7. | 女性 (female)
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| 8. | (英) Fusobacterium nucleatum (日) (読)
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| 9. | (英) Hematologic Neoplasms (日) (読)
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| 10. | (英) Humans (日) (読)
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| 11. | (英) Immunoglobulin A, Secretory (日) (読)
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| 12. | 男性 (male)
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| 13. | (英) Middle Aged (日) (読)
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| 14. | (英) Mouth (日) (読)
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| 15. | (英) Risk Factors (日) (読)
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| 16. | (英) Young Adult (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | International Journal of Hematology (日本血液学会)
(pISSN: 0925-5710, eISSN: 1865-3774)
| ○ISSN (任意): | □ | 1865-3774
ISSN: 0925-5710
(pISSN: 0925-5710, eISSN: 1865-3774) Title: International journal of hematologyTitle(ISO): Int J HematolPublisher: Springer (NLM Catalog)
(医中誌Web)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 112
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 851 859
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2020年 12月 初日 (令和 2年 12月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s12185-020-02975-x (→Scopusで検索)
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| ○PMID (任意): | □ | 32880823 (→Scopusで検索)
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| ○NAID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-85090162636
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| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1007/s12185-020-02975-x (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Fever with neutropenia (日)
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| 4. | (英) KeywordList.Keyword: Fusobacterium nucleatum (日)
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| 5. | (英) KeywordList.Keyword: Hematological cancer (日)
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| 6. | (英) KeywordList.Keyword: Risk factor (日)
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| 7. | (英) KeywordList.Keyword: Secretory immunoglobulin A (日)
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