『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=339754)

EID=339754EID:339754, Map:0, LastModified:2019年8月7日(水) 13:39:57, Operator:[山本 武範], Avail:TRUE, Censor:0, Owner:[山本 武範], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) [継承]
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著者 (必須): 1.山本 武範
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2. (英) Tsunoda Moe (日) 角田 萌 (読) つのだ もえ
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学籍番号 (推奨): **** [ユーザ]
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3. (英) Ozono Mizune (日) 大園 瑞音 (読) おおぞの みずね
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学籍番号 (推奨): **** [ユーザ]
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4. (英) Watanabe Akira (日) 渡辺 朗 (読) わたなべ あきら
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5. (英) Kotake Kazumasa (日) 小武 和正 (読) こたけ かずまさ
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学籍番号 (推奨): **** [ユーザ]
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6.廣島 佑香 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔微生物学])
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7.山田 安希子
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8.寺田 弘 ([東京理科大学])
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9.篠原 康雄 ([徳島大学.先端酵素学研究所.基幹研究部門])
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題名 (必須): (英) Polyethyleneimine renders mitochondrial membranes permeable by interacting with negatively charged phospholipids in them  (日)    [継承]
副題 (任意):
要約 (任意): (英) Polyethyleneimines (PEIs) are used for transfection of cells with nucleic acids. Meanwhile, the interaction of PEI with mitochondria causes cytochrome c release prior to apoptosis; the mechanisms how PEI causes this permeabilization of mitochondrial membranes and the release of cytochrome c remain unclear. To clarify these mechanisms, we examined the effects of branched-type PEI and linear-type PEI, each of which was 25 kDa in size, on mitochondria. The permeabilization potency of mitochondrial membranes by branched PEI was stronger than that by linear PEI. The permeabilization by PEIs were insensitive to permeability-transition inhibitors, indicating that PEI-induced permeabilization was not attributed to permeability transition. Meanwhile, PEIs caused permeabilization of artificial lipid vesicles; again, the permeabilization potency of branched PEI was stronger than that of linear PEI. Such a difference in this potency was close to that in the case of isolated mitochondria, signifying that the PEI-induced permeabilization of mitochondrial membranes could be attributed to PEI's interaction with the phospholipid phase. Furthermore, this PEI-induced permeabilization of the lipid vesicles was observed only in the case of lipid vesicles including negatively charged phospholipids. These results indicate that PEIs interacted with negatively charged phospholipids in the mitochondrial membranes to directly lead to their permeabilization.  (日)    [継承]
キーワード (推奨):
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誌名 (必須): Archives of Biochemistry and Biophysics ([Elsevier])
(pISSN: 0003-9861, eISSN: 1096-0384)

ISSN (任意): 1096-0384
ISSN: 0003-9861 (pISSN: 0003-9861, eISSN: 1096-0384)
Title: Archives of biochemistry and biophysics
Title(ISO): Arch Biochem Biophys
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2018年 6月 7日 (平成 30年 6月 7日) [継承]
URL (任意):
DOI (任意): 10.1016/j.abb.2018.06.003    (→Scopusで検索) [継承]
PMID (任意): 29886045    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: S0003-9861(18)30152-8  (日)    [継承]
2.(英) Article.ELocationID: 10.1016/j.abb.2018.06.003  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) KeywordList.Keyword: Cytochrome c  (日)    [継承]
5.(英) KeywordList.Keyword: Lipid phase  (日)    [継承]
6.(英) KeywordList.Keyword: Mitochondria  (日)    [継承]
7.(英) KeywordList.Keyword: Permeability transition  (日)    [継承]
8.(英) KeywordList.Keyword: Polyethyleneimine  (日)    [継承]

標準的な表示

和文冊子 ● Takenori Yamamoto, Moe Tsunoda, Mizune Ozono, Akira Watanabe, Kazumasa Kotake, Yuka Hiroshima, Akiko Yamada, Hiroshi Terada and Yasuo Shinohara : Polyethyleneimine renders mitochondrial membranes permeable by interacting with negatively charged phospholipids in them, Archives of Biochemistry and Biophysics, 2018.
欧文冊子 ● Takenori Yamamoto, Moe Tsunoda, Mizune Ozono, Akira Watanabe, Kazumasa Kotake, Yuka Hiroshima, Akiko Yamada, Hiroshi Terada and Yasuo Shinohara : Polyethyleneimine renders mitochondrial membranes permeable by interacting with negatively charged phospholipids in them, Archives of Biochemistry and Biophysics, 2018.

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