『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=339607EID:339607, Map:0, LastModified:2018年12月2日(日) 21:34:07, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[吉田 賀弥], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 国際共著 (徳島大学内研究者と国外研究機関所属研究者との共同研究) [継承]
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.吉田 賀弥 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健教育学]/[徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座])
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[継承]
2.寺町 順平
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[継承]
3. (英) Uchibe Kenta (日) (読)
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[継承]
4. (英) Ikegame Mika (日) (読)
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[継承]
5. (英) Qiu Lihong (日) (読)
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[継承]
6.楊 諦
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[継承]
7.岡村 裕彦
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[継承]
題名 (必須): (英) Reduction of protein phosphatase 2A Ca promotes in vivo bone formation and adipocyte differentiation.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Serine/threonine protein phosphatase 2A (PP2A) regulates diverse physiological processes such as cell cycle, growth, apoptosis, and signal transduction. Previously, we demonstrated that silencing of the α-isoform of PP2A catalytic subunit (PP2A Cα) in osteoblasts accelerated osteoblast differentiation, whereas its overexpression suppressed differentiation. In this study, we examined the role of PP2A Cα in in vivo bone formation by generating transgenic mice (PP2A-Tg), in which the dominant negative form of PP2A Cα was specifically expressed in osteoblasts. PP2A-Tg mice exhibited an increase in body weight, cortical bone mineral density, and cortical bone thickness. Interestingly, they also displayed higher amounts of adipose tissue in the bone marrow of tibiae. The co-culture study showed that PP2A Cα-knockdown osteoblasts stimulated adipocyte differentiation from undifferentiated mesenchymal cells via upregulation of the adipocyte marker genes, such as peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα). These results indicated that the reduction of PP2A Cα levels in osteoblasts promoted bone formation in vivo. Additionally, PP2A Cα in osteoblasts was also potentially involved in controlling adipocyte differentiation through a paracrine mechanism.  (日)    [継承]
キーワード (推奨):
発行所 (推奨):
誌名 (必須): Molecular and Cellular Endocrinology ([Elsevier])
(pISSN: 0303-7207, eISSN: 1872-8057)

ISSN (任意): 1872-8057
ISSN: 0303-7207 (pISSN: 0303-7207, eISSN: 1872-8057)
Title: Molecular and cellular endocrinology
Title(ISO): Mol Cell Endocrinol
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 470 [継承]
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(必須): 251 258 [継承]
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年月日 (必須): 西暦 2018年 0月 初日 (平成 30年 0月 初日) [継承]
URL (任意):
DOI (任意): 10.1016/j.mce.2017.11.005    (→Scopusで検索) [継承]
PMID (任意): 29128580    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-85033794901 [継承]
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備考 (任意): 1.(英) Article.ELocationID: S0303-7207(17)30570-1  (日)    [継承]
2.(英) Article.ELocationID: 10.1016/j.mce.2017.11.005  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) KeywordList.Keyword: Adipocyte  (日)    [継承]
5.(英) KeywordList.Keyword: Differentiation  (日)    [継承]
6.(英) KeywordList.Keyword: Osteoblast  (日)    [継承]
7.(英) KeywordList.Keyword: Protein phosphatase  (日)    [継承]

標準的な表示

和文冊子 ● Kaya Yoshida, Jumpei Teramachi, Kenta Uchibe, Mika Ikegame, Lihong Qiu, Di Yang and Hirohiko Okamura : Reduction of protein phosphatase 2A Ca promotes in vivo bone formation and adipocyte differentiation., Molecular and Cellular Endocrinology, Vol.470, 251-258, 2018.
欧文冊子 ● Kaya Yoshida, Jumpei Teramachi, Kenta Uchibe, Mika Ikegame, Lihong Qiu, Di Yang and Hirohiko Okamura : Reduction of protein phosphatase 2A Ca promotes in vivo bone formation and adipocyte differentiation., Molecular and Cellular Endocrinology, Vol.470, 251-258, 2018.

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