| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | 山﨑 幹雄
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| 2. | 桑原 章
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| 3. | 岩佐 武 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.産科婦人科学])
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| 4. | 山本 由理 ([徳島大学.病院.中央診療施設等.地域産婦人科診療部]/[徳島大学.病院.診療科.小児·周産·女性科.産科婦人科])
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| 5. | (英) Taniguchi Yuka (日) 谷口 友香 (読) たにぐち ゆか
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| ○学籍番号 (推奨): | □ | ****
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| 6. | (英) Yano Yuya (日) (読)
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| 7. | 松井 寿美佳
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| 8. | 松崎 利也
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| 9. | 苛原 稔
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| ○題名 (必須): | □ | (英) Development-related changes in the expression of the ovarian Kiss1 and Kiss1r genes and their sensitivity to human chorionic gonadotropin in prepubertal female rats. (日)
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| ○要約 (任意): | □ | (英) Kisspeptin, which is encoded by the Kiss1 gene, and its receptor, the G protein-coupled receptor 54 (Kiss1r), play important roles in the regulation of reproductive functions in mammals. Several studies have shown that the Kiss1 and Kiss1r genes are expressed in the rat, primate, and human ovaries, and that the ovarian kisspeptin system plays a pivotal role in ovulation at the proestrous stage in adulthood. The purpose of this study was to evaluate development-related changes in the expression of ovarian Kiss1 and Kiss1r genes and in kisspeptin levels, and to identify the regulatory factors for these genes during the prepubertal period. The serum kisspeptin level was also measured to examine whether ovarian kisspeptin affects serum kisspeptin levels. Variations in the ovarian Kiss1 and Kiss1r mRNA levels were observed during the prepubertal period in female rats, with levels peaking around postnatal days 20 and 15, respectively. Nevertheless, the ovarian kisspeptin content per total protein level was stably maintained. Serum kisspeptin levels at postnatal days 30 and 35 were higher than those at earlier postnatal days. The pattern of the ovarian Kiss1 mRNA levels was similar to that of the serum luteinizing hormone (LH) levels, and the ovarian Kiss1 mRNA level increased after injection with human chorionic gonadotropin (HCG) on postnatal day 20, but not on postnatal days 10 and 30. These data indicate that ovarian Kiss1 and Kiss1r mRNA levels are increased on postnatal days 20 and 15, respectively, and that changes in the serum LH level and the ovarian sensitivity to LH may be involved in the alteration of ovarian Kiss1 mRNA levels. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Chorionic Gonadotropin (日) (読)
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| 3. | (英) Female (日) (読)
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| 4. | (英) Gene Expression Regulation, Developmental (日) (読)
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| 5. | (英) Kisspeptins (日) (読)
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| 6. | (英) Ovary (日) (読)
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| 7. | (英) Rats (日) (読)
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| 8. | (英) Rats, Sprague-Dawley (日) (読)
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| 9. | (英) Receptors, Kisspeptin-1 (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Reproduction and Development (日本繁殖生物学会)
(pISSN: 0916-8818, eISSN: 1348-4400)
| ○ISSN (任意): | □ | 1348-4400
ISSN: 0916-8818
(pISSN: 0916-8818, eISSN: 1348-4400) Title: The Journal of reproduction and developmentTitle(ISO): J Reprod DevSupplier: 公益社団法人 日本繁殖生物学会Publisher: The Japanese Society of Animal Reproduction (JSAR) (NLM Catalog)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 63
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 409 414
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2017年 5月 27日 (平成 29年 5月 27日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1262/jrd.2016-179 (→Scopusで検索)
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| ○PMID (任意): | □ | 28552864 (→Scopusで検索)
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| ○機関リポジトリ : | □ | 112975
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1262/jrd.2016-179 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Development (日)
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| 4. | (英) KeywordList.Keyword: Kiss1 (日)
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| 5. | (英) KeywordList.Keyword: Kiss1r (日)
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| 6. | (英) KeywordList.Keyword: Ovary (日)
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| 7. | (英) KeywordList.Keyword: kisspeptin (日)
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