| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): | □ | 学士課程学生による研究報告
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Ishikawa Misuzu (日) 石川 みすず (読) いしかわ みすず
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| ○学籍番号 (推奨): | □ | ****
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| 2. | (英) Hirai Shota (日) 平井 将太 (読) ひらい しょうた
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| ○学籍番号 (推奨): | □ | ****
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| 3. | 吉田 達貞
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| 4. | (英) Shibuya Natsumi (日) 渋谷 菜摘 (読) しぶや なつみ
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| ○学籍番号 (推奨): | □ | ****
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| 5. | (英) Hama, Susumu (日) 濵 進 (読) はま すすむ
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| 6. | (英) Takahashi Yu (日) 高橋 侑 (読) たかはし ゆう
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| 7. | 福田 達也
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| 8. | 田中 保 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.食料科学系.食料科学分野])
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| 9. | (英) Hosoi Shinzo (日) 細井 信造 (読) ほそい しんぞう
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| 10. | 小暮 健太朗 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.衛生薬学])
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| ○題名 (必須): | □ | (英) Carotenoid Stereochemistry Affects Antioxidative Activity of Liposomes Co-encapsulating Astaxanthin and Tocotrienol (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) We previously found that antioxidative activity of liposomes co-encapsulating astaxanthin (Asx) and tocotrienols (T3s) was higher than the calculated additive activity, which results from intermolecular interactions between both antioxidants (J. Clin. Biochem. Nutr., 59, 2016, Kamezaki et al.). Herein, we conducted experiments to optimize Asx/α-T3 ratio for high antioxidative activity, and tried to elucidate details of intermolecular interaction of Asx with α-T3. Higher activity than calculated additive value was clearly observed at an Asx/α-T3 ratio of 2 : 1, despite two α-T3 would potentially interact with two terminal rings of one Asx. The synthetic Asx used in this study was a mixture of three stereoisomers, 3R,3'R-form (Asx-R), 3S,3'S-form (Asx-S) and 3R,3'S-meso form (Asx-meso). The calculated binding energy of the Asx-S/α-T3 complex was higher than those of Asx-R/α-T3 and Asx-meso/α-T3, suggesting that Asx-S and α-T3 is the most preferable combination for the intermolecular interaction. The optimal Asx-S/α-T3 ratio for antioxidation was shown to be 1 : 2. These results suggest that the Asx stereochemistry affects the intermolecular interaction of Asx/α-T3. Moreover, the absorption spectrum changes of Asx-S upon co-encapsulation with α-T3 in liposomes indicate that the electronic state of Asx-S is affected by intermolecular interactions with α-T3. Further, intermolecular interactions with α-T3 affected the electronic charges on the C9, C10 and C15 atoms in the polyene moiety of Asx-S. In conclusion, the intermolecular interaction of Asx/T3 depends on the Asx stereochemistry, and caused a change in the electronic state of the Asx polyene moiety by the presence of double bond in the T3 triene moiety. (日)
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| ○キーワード (推奨): | 1. | (英) Antioxidants (日) (読)
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| 2. | カロテノイド (carotenoids)
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| 3. | リポソーム (liposomes)
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| 4. | 分子構造 (molecular structure)
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| 5. | (英) Stereoisomerism (日) (読)
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| 6. | (英) Tocotrienols (日) (読)
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| 7. | (英) Xanthophylls (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Chemical & Pharmaceutical Bulletin ([日本薬学会])
(pISSN: 0009-2363, eISSN: 1347-5223)
| ○ISSN (任意): | □ | 1347-5223
ISSN: 0009-2363
(pISSN: 0009-2363, eISSN: 1347-5223) Title: Chemical & pharmaceutical bulletinTitle(ISO): Chem Pharm Bull (Tokyo)Supplier: 公益社団法人日本薬学会Publisher: Pharmaceutical Society of Japan (NLM Catalog)
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| ○巻 (必須): | □ | 66
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| ○号 (必須): | □ | 7
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| ○頁 (必須): | □ | 714 720
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2018年 5月 初日 (平成 30年 5月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1248/cpb.c18-00035 (→Scopusで検索)
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| ○PMID (任意): | □ | 29962454 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-85049232130
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| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): | 1. | 小暮 健太朗 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.衛生薬学])
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1248/cpb.c18-00035 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: antioxidation (日)
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| 4. | (英) KeywordList.Keyword: astaxanthin stereoisomer (日)
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| 5. | (英) KeywordList.Keyword: intermolecular interaction (日)
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| 6. | (英) KeywordList.Keyword: tocotrienol (日)
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