『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=338506)

EID=338506EID:338506, Map:0, LastModified:2018年12月27日(木) 13:12:37, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) [継承]
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院社会産業理工学研究部.生物資源産業学域 (2017年4月1日〜) [継承]
著者 (必須): 1. (英) Osaki Tomohiro (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Sakata Isao (日) (読)
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学籍番号 (推奨):
[継承]
3.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Azuma Kazuo (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Murahata Yusuke (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Tsuka Takeshi (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Itoh Norihiko (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Imagawa Tomohiro (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
9. (英) Okamoto Yoshiharu (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Photodynamic Therapy Mediated by a Novel Chlorin Derivative, TONS 501-Na, in EMT6 cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The lipophilic photosensitizer, TONS 501, is a novel porphyrin-derived methyl ester that was developed for photodynamic antimicrobial chemotherapy. This study developed a hydrophilic and anionic porphyrin salt of this compound (TONS 501-Na) for use in photodynamic therapy (PDT). This chlorin derivative is synthesized from the protoporphyrin IX dimethyl ester. We investigated the in vitro cytotoxic effects of TONS 501-Na-mediated PDT on EMT6 mouse breast cancer cells. EMT6 cells were incubated with 0-100 μg/ml TONS 501-Na for 24 h prior to replacing the culture medium and exposing the cells to 6 mW/cm diode laser irradiation at 0-13 J/cm to induce PDT. Morphological changes and cell viability were evaluated 24 h after PDT. The percentages of apoptotic cells were evaluated 4 h and 24 h after PDT. The concentrations of TONS 501-Na that killed 50% of EMT6 cells after exposure to light doses of 0, 0.4, 3, 6, or 13 J/cm were 84.6, 33.2, 18, 8.2, and 2.2 μg/ml, respectively. Tumor cells exposed to PDT showed chromatin condensation and fragmentation. The percentages of apoptotic cells increased in a TONS 501-Na concentration-dependent manner in the PDT group, and were significantly higher than those in the control group or in cells treated with TONS 501-Na or laser irradiation alone. TONS 501-Na-mediated PDT induced mouse breast cancer cell death in a concentration-dependent manner. Future studies should evaluate the in vivo pharmacokinetics, tissue distribution, and photodynamic effects of TONS 501-Na.  (日)    [継承]
キーワード (推奨): 1.アポトーシス (apoptosis) [継承]
2. (英) TONS 501-Na (日) (読) [継承]
3. (英) photodynamic therapy (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Anticancer Research (International Institute of Anticancer Research(IIAR))
(pISSN: 0250-7005, eISSN: 1791-7530)

ISSN (任意): 1791-7530
ISSN: 0250-7005 (pISSN: 0250-7005, eISSN: 1791-7530)
Title: Anticancer research
Title(ISO): Anticancer Res.
Publisher: International Institute of Anticancer Research
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 37 [継承]
(必須): 4 [継承]
(必須): 1723 1728 [継承]
都市 (任意):
年月日 (必須): 西暦 2017年 4月 初日 (平成 29年 4月 初日) [継承]
URL (任意):
DOI (任意): 10.21873/anticanres.11504    (→Scopusで検索) [継承]
PMID (任意): 28373434    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-85017456224 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) KeywordList.Keyword: Apoptosis  (日)    [継承]
3.(英) KeywordList.Keyword: TONS 501-Na  (日)    [継承]
4.(英) KeywordList.Keyword: photodynamic therapy  (日)    [継承]

標準的な表示

和文冊子 ● Tomohiro Osaki, Isao Sakata, Yoshihiro Uto, Kazuo Azuma, Yusuke Murahata, Takeshi Tsuka, Norihiko Itoh, Tomohiro Imagawa and Yoshiharu Okamoto : Photodynamic Therapy Mediated by a Novel Chlorin Derivative, TONS 501-Na, in EMT6 cells., Anticancer Research, Vol.37, No.4, 1723-1728, 2017.
欧文冊子 ● Tomohiro Osaki, Isao Sakata, Yoshihiro Uto, Kazuo Azuma, Yusuke Murahata, Takeshi Tsuka, Norihiko Itoh, Tomohiro Imagawa and Yoshiharu Okamoto : Photodynamic Therapy Mediated by a Novel Chlorin Derivative, TONS 501-Na, in EMT6 cells., Anticancer Research, Vol.37, No.4, 1723-1728, 2017.

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