『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.毛利 安宏 ([徳島大学.大学院医歯薬学研究部.歯学域.先端歯学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Ueda Yoshihiro (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Yamano Tomoyoshi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Matsumoto Minoru (日) 松本 穣 (読) まつもと みのる
役割 (任意):
貢献度 (任意):
学籍番号 (推奨): **** [ユーザ]
[継承]
5.常山 幸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Kinashi Tatsuo (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7.松本 満 ([徳島大学.先端酵素学研究所.重点研究部門])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Mode of tolerance induction and requirement for Aire are governed by the cell types that express self-antigen and those that present antigen  (日)    [継承]
副題 (任意):
要約 (任意): (英) Aire controls the fate of autoreactive thymocytes (i.e., clonal deletion or development into regulatory T cells [Tregs]) through transcriptional control of the expression of tissue-restricted self-antigens (TRAs) from medullary thymic epithelial cells (mTECs) and bone marrow (BM)-derived cells. Although TRAs expressed by mTECs and BM-derived cells are suggested to complement each other to generate a full spectrum of TRAs, little is known about the relative contribution of TRAs from each component for establishment of self-tolerance. Furthermore, the precise role of Aire in specific types of Aire-expressing APCs remains elusive. We have approached these issues by generating two different types of transgenic mouse (Tg) model, which express a prefixed model self-antigen driven by the insulin promoter or the Aire promoter. In the insulin-promoter Tg model, mTECs alone were insufficient for clonal deletion, and BM-derived APCs were required for this action by utilizing Ag transferred from mTECs. In contrast, mTECs alone were able to induce Tregs, although at a much lower efficiency in the absence of BM-derived APCs. Importantly, lack of Aire in mTECs, but not in BM-derived APCs, impaired both clonal deletion and production of Tregs. In the Aire-promoter Tg model, both mTECs and BM-derived APCs could independently induce clonal deletion without Aire, and production of Tregs was impaired by the lack of Aire in mTECs, but not in BM-derived APCs. These results suggest that the fate of autoreactive thymocytes together with the requirement for Aire depend on the cell types that express self-antigens and the types of APCs involved in tolerance induction.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antigen Presentation (日) (読) [継承]
3. (英) Antigen-Presenting Cells (日) (読) [継承]
4. (英) Autoantigens (日) (読) [継承]
5. (英) Clonal Deletion (日) (読) [継承]
6. (英) Epithelial Cells (日) (読) [継承]
7. (英) Female (日) (読) [継承]
8. (英) Gene Expression Regulation (日) (読) [継承]
9. (英) Gene Knock-In Techniques (日) (読) [継承]
10. (英) Genes, Synthetic (日) (読) [継承]
11.インスリン (insulin) [継承]
12. (英) Male (日) (読) [継承]
13. (英) Mice (日) (読) [継承]
14. (英) Mice, Inbred C57BL (日) (読) [継承]
15.ノックアウトマウス (knockout mice) [継承]
16. (英) Mice, Transgenic (日) (読) [継承]
17. (英) Ovalbumin (日) (読) [継承]
18. (英) Promoter Regions, Genetic (日) (読) [継承]
19. (英) Rats (日) (読) [継承]
20. (英) Specific Pathogen-Free Organisms (日) (読) [継承]
21. (英) T-Lymphocytes, Regulatory (日) (読) [継承]
22. (英) Thymus Gland (日) (読) [継承]
23. (英) Transcription Factors (日) (読) [継承]
24. (英) Transgenes (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
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(必須): 199 [継承]
(必須): 12 [継承]
(必須): 3959 3971 [継承]
都市 (任意):
年月日 (必須): 西暦 2017年 11月 3日 (平成 29年 11月 3日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.1700892    (→Scopusで検索) [継承]
PMID (任意): 29101311    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意): 2-s2.0-85038566360 [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Yasuhiro Mouri, Yoshihiro Ueda, Tomoyoshi Yamano, Minoru Matsumoto, Koichi Tsuneyama, Tatsuo Kinashi and Mitsuru Matsumoto : Mode of tolerance induction and requirement for Aire are governed by the cell types that express self-antigen and those that present antigen, The Journal of Immunology, Vol.199, No.12, 3959-3971, 2017.
欧文冊子 ● Yasuhiro Mouri, Yoshihiro Ueda, Tomoyoshi Yamano, Minoru Matsumoto, Koichi Tsuneyama, Tatsuo Kinashi and Mitsuru Matsumoto : Mode of tolerance induction and requirement for Aire are governed by the cell types that express self-antigen and those that present antigen, The Journal of Immunology, Vol.199, No.12, 3959-3971, 2017.

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