『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=336399)

EID=336399EID:336399, Map:0, LastModified:2019年9月18日(水) 09:26:05, Operator:[大東 いずみ], Avail:TRUE, Censor:0, Owner:[高浜 洋介], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 単独著作 (徳島大学内の単一の研究グループ(研究室等)内の研究 (単著も含む)) [継承]
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Sakata Mie (日) 坂田 三恵 (読) さかた みえ
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2.大東 いずみ ([徳島大学.先端酵素学研究所.重点研究部門])
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3.高浜 洋介
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題名 (必須): (英) Cellularity of Thymic Epithelial Cells in the Postnatal Mouse.  (日)    [継承]
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要約 (任意): (英) The molecular and cellular biology of thymic epithelial cells (TECs) often relies on the analysis of TECs isolated in enzymatically digested single-cell suspensions derived from mouse thymus. Many independent studies have reported that the estimated cellularity of total TECs isolated from one adult mouse is on the order of up to 10 However, these numbers appear extremely small given that the cellularity of total thymocytes exceeds 10 and that TECs play multiple roles in thymocyte development and repertoire formation. In the present study, we aimed to measure the numbers of β5t-expressing cortical TECs and Aire-expressing medullary TECs in postnatal mouse thymus in situ without enzymatic digestion. The numbers of these TECs were manually counted in individual thymic sections and were three-dimensionally summed throughout the entire thymic lobes. The results show that the cellularity of total TECs in one 5-wk-old female mouse exceeds 10, containing 9 × 10 β5t cortical TECs and 1.1 × 10 Aire medullary TECs. These results suggest that the use of conventional enzymatic digestion methods for the isolation of TECs may have resulted in the underestimation of the cellularity, and possibly the biology, of TECs.  (日)    [継承]
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誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 200 [継承]
(必須): 4 [継承]
(必須): 1382 1388 [継承]
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年月日 (必須): 西暦 2018年 2月 15日 (平成 30年 2月 15日) [継承]
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DOI (任意): 10.4049/jimmunol.1701235    (→Scopusで検索) [継承]
PMID (任意): 29298829    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-85044773413 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.4049/jimmunol.1701235  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Mie Sakata, Izumi Ohigashi and Yousuke Takahama : Cellularity of Thymic Epithelial Cells in the Postnatal Mouse., The Journal of Immunology, Vol.200, No.4, 1382-1388, 2018.
欧文冊子 ● Mie Sakata, Izumi Ohigashi and Yousuke Takahama : Cellularity of Thymic Epithelial Cells in the Postnatal Mouse., The Journal of Immunology, Vol.200, No.4, 1382-1388, 2018.

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