| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Ishihara Akinori (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | 沢津橋 俊 ([徳島大学.先端酵素学研究所.技術開発支援部門])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Yamauchi Kiyoshi (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Endocrine disrupting chemicals: interference of thyroid hormone binding to transthyretins and to thyroid hormone receptors. (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) We examined the effects of industrial, medical and agricultural chemicals on 3,5,3'-L-[125I]triiodothyronine ([125I]T(3)) binding to transthyretins (TTRs) and thyroid hormone receptors (TRs). Among the chemicals investigated diethylstilbestrol (DES) was the most powerful inhibitor of [125I]T(3) binding to chicken and bullfrog TTR (cTTR and bTTR). Inhibition of [125I]T(3) binding was more apparent in cTTR than bTTR. Scatchard analysis revealed DES, pentachlorophenol and ioxynil as competitive inhibitors of [125I]T(3) binding to cTTR and bTTR. However, cTTR's affinity for the three chemicals was higher than its affinity for T(3). A miticide dicofol (10(-10)-10(-7) M) activated [125I]T(3) binding to bTTR up to 170%. However, at 4x10(-5) M it inhibited [125I]T(3) binding by 83%. Dicofol's biphasic effect upon [125I]T(3) binding was not detected in TTRs from other species. DES and pentachlorophenol, in the presence of plasma, increased cellular uptake of [125I]T(3) in vitro, by displacing [125I]T(3) from its plasma binding sites. These chemicals did not, however, affect the association of cTTR with chicken retinol-binding protein. All chemicals investigated had little or no influence on [125I]T(3) binding to chicken TR (cTR) and bullfrog TR (bTR). Several endocrine disrupting chemicals that were tested interfered with T(3) binding to TTR rather than to TR. Binding of the endocrine disrupting chemicals to TTR may weaken their intrinsic effects on target cells by depressing their free concentrations in plasma. However, this may affect TH homeostasis in vivo by altering the free concentrations of plasma THs. (日)
| [継承] |
| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
| [継承] |
| 2. | (英) Binding, Competitive (日) (読)
| [継承] |
| 3. | (英) Carrier Proteins (日) (読)
| [継承] |
| 4. | (英) Chickens (日) (読)
| [継承] |
| 5. | (英) Endocrine System (日) (読)
| [継承] |
| 6. | (英) Erythrocytes (日) (読)
| [継承] |
| 7. | (英) Humans (日) (読)
| [継承] |
| 8. | (英) Iodine Radioisotopes (日) (読)
| [継承] |
| 9. | (英) Membrane Proteins (日) (読)
| [継承] |
| 10. | (英) Organic Chemicals (日) (読)
| [継承] |
| 11. | (英) Prealbumin (日) (読)
| [継承] |
| 12. | (英) Protein Binding (日) (読)
| [継承] |
| 13. | (英) Rana catesbeiana (日) (読)
| [継承] |
| 14. | (英) Receptors, Thyroid Hormone (日) (読)
| [継承] |
| 15. | (英) Salmon (日) (読)
| [継承] |
| 16. | (英) Thyroid Hormones (日) (読)
| [継承] |
| 17. | (英) Triiodothyronine (日) (読)
| [継承] |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Molecular and Cellular Endocrinology ([Elsevier])
(pISSN: 0303-7207, eISSN: 1872-8057)
| ○ISSN (任意): | □ | 0303-7207
ISSN: 0303-7207
(pISSN: 0303-7207, eISSN: 1872-8057) Title: Molecular and cellular endocrinologyTitle(ISO): Mol Cell EndocrinolPublisher: Elsevier BV (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 199
| [継承] |
| ○号 (必須): | □ | 1-2
| [継承] |
| ○頁 (必須): | □ | 105 117
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2003年 1月 31日 (平成 15年 1月 31日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/S0303-7207(02)00302-7 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 12581883 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
| [継承] |
| 2. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
| [継承] |