| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○著者 (必須): | 1. | 沢津橋 俊 ([徳島大学.先端酵素学研究所.技術開発支援部門])
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| 2. | (英) Maki Akio (日) (読)
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| 3. | (英) Ito Saya (日) (読)
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| 4. | (英) Shirode Yuko (日) (読)
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| 5. | (英) Suzuki Eriko (日) (読)
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| 6. | (英) Zhao Yue (日) (読)
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| 7. | (英) Yamagata Kaoru (日) (読)
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| 8. | (英) Kouzmenko Alexander (日) (読)
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| 9. | (英) Takeyama Ken-Ichi (日) (読)
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| 10. | (英) Kato Shigeaki (日) (読)
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| ○題名 (必須): | □ | (英) Ecdysone receptor-dependent gene regulation mediates histone poly(ADP-ribosyl)ation. (日)
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| ○要約 (任意): | □ | (英) While the ecdysone dependency of puff formation in giant polytene chromosomes from fly salivary glands has been well documented, the molecular mechanisms underlying this process remain unknown. However, it does appear to involve chromatin remodeling and modification mediated by ecdysone receptor (EcR). As Drosophila poly(ADP-ribose) polymerase (dPARP) has recently been reported to be involved in ecdysone-induced puff formation, we decided to test the possible role of dPARP in ligand-induced dEcR transactivation in an insect system. dPARP co-activated the ligand-induced transactivation function of EcR in the insect cell line S2, and appeared to physically interact with EcR in a ligand-dependent manner. ChIP analysis of an EcR target gene promoter revealed ligand-dependent recruitment of dPARP with poly(ADP-ribosyl)ation of histones in the EcR binding site and, surprisingly, also in a distal region of the promoter. Our results indicated that EcR-mediated gene regulation may be coupled with chromatin modification through poly(ADP-ribosyl)ation. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Cell Line (日) (読)
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| 3. | (英) Drosophila melanogaster (日) (読)
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| 4. | (英) Gene Expression Regulation (日) (読)
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| 5. | (英) Histones (日) (読)
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| 6. | (英) Poly(ADP-ribose) Polymerases (日) (読)
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| 7. | (英) Receptors, Steroid (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)
| ○ISSN (任意): | □ | 0006-291X
ISSN: 0006-291X
(pISSN: 0006-291X, eISSN: 1090-2104) Title: Biochemical and biophysical research communicationsTitle(ISO): Biochem Biophys Res CommunPublisher: Elsevier Inc. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 320
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 268 272
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2004年 7月 16日 (平成 16年 7月 16日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.bbrc.2004.05.157 (→Scopusで検索)
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| ○PMID (任意): | □ | 15207731 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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| 2. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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