| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Zhao Yue (日) (読)
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| ○学籍番号 (推奨): |
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| 2. | (英) Takeyama Ken-ichi (日) (読)
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| 3. | 沢津橋 俊 ([徳島大学.先端酵素学研究所.技術開発支援部門])
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| 4. | (英) Ito Saya (日) (読)
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| 5. | (英) Suzuki Eriko (日) (読)
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| 6. | (英) Yamagata Kaoru (日) (読)
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| 7. | (英) Tanabe Masahiko (日) (読)
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| 8. | (英) Kimura Shuhei (日) (読)
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| 9. | (英) Fujiyama Sally (日) (読)
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| 10. | (英) Ueda Takashi (日) (読)
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| 11. | (英) Murata Takuya (日) (読)
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| ○貢献度 (任意): |
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| 12. | (英) Matsukawa Hiroyuki (日) (読)
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| 13. | (英) Shirode Yuko (日) (読)
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| [継承] |
| 14. | (英) Kouzmenko Alexander P (日) (読)
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| ○貢献度 (任意): |
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| [継承] |
| 15. | (英) Li Feng (日) (読)
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| ○貢献度 (任意): |
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| [継承] |
| 16. | (英) Tabata Testuya (日) (読)
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| [継承] |
| 17. | (英) Kato Shigeaki (日) (読)
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| ○貢献度 (任意): |
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| ○題名 (必須): | □ | (英) Corepressive action of CBP on androgen receptor transactivation in pericentric heterochromatin in a Drosophila experimental model system. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Ligand-bound nuclear receptors (NR) activate transcription of the target genes. This activation is coupled with histone modifications and chromatin remodeling through the function of various coregulators. However, the nature of the dependence of a NR coregulator action on the presence of the chromatin environment at the target genes is unclear. To address this issue, we have developed a modified position effect variegation experimental model system that includes an androgen-dependent reporter transgene inserted into either a pericentric heterochromatin region or a euchromatic region of Drosophila chromosome. Human androgen receptor (AR) and its constitutively active truncation mutant (AR AF-1) were transcriptionally functional in both chromosomal regions. Predictably, the level of AR-induced transactivation was lower in the pericentric heterochromatin. In genetic screening for AR AF-1 coregulators, Drosophila CREB binding protein (dCBP) was found to corepress AR transactivation at the pericentric region whereas it led to coactivation in the euchromatic area. Mutations of Sir2 acetylation sites or deletion of the CBP acetyltransferase domain abrogated dCBP corepressive action for AR at heterochromatic areas in vivo. Such a CBP corepressor function for AR was observed in the transcriptionally silent promoter of an AR target gene in cultured mammalian cells. Thus, our findings suggest that the action of NR coregulators may depend on the state of chromatin at the target loci. (日)
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| ○キーワード (推奨): | 1. | (英) Acetylation (日) (読)
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| 2. | (英) Amino Acid Sequence (日) (読)
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| 3. | (英) Animals (日) (読)
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| 4. | (英) CREB-Binding Protein (日) (読)
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| 5. | (英) Catalytic Domain (日) (読)
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| 6. | (英) Cell Line, Tumor (日) (読)
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| 7. | (英) Chromosomal Position Effects (日) (読)
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| 8. | (英) Conserved Sequence (日) (読)
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| 9. | (英) Drosophila Proteins (日) (読)
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| 10. | (英) Drosophila melanogaster (日) (読)
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| 11. | (英) Euchromatin (日) (読)
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| 12. | (英) Heterochromatin (日) (読)
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| 13. | (英) Histone Deacetylases (日) (読)
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| 14. | (英) Histones (日) (読)
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| 15. | (英) Humans (日) (読)
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| 16. | (英) Lysine (日) (読)
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| 17. | (英) Methylation (日) (読)
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| 18. | (英) Models, Genetic (日) (読)
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| 19. | (英) Molecular Sequence Data (日) (読)
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| 20. | (英) Promoter Regions, Genetic (日) (読)
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| 21. | (英) Receptors, Androgen (日) (読)
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| 22. | (英) Repressor Proteins (日) (読)
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| 23. | (英) Sirtuins (日) (読)
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| 24. | (英) Transcriptional Activation (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Molecular and Cellular Biology ([アメリカ微生物学会])
(pISSN: 0270-7306, eISSN: 1098-5549)
| ○ISSN (任意): | □ | 1098-5549
ISSN: 0270-7306
(pISSN: 0270-7306, eISSN: 1098-5549) Title: Molecular and cellular biologyTitle(ISO): Mol Cell BiolPublisher: American Society for Microbiology (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 29
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 1017 1034
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2008年 12月 15日 (平成 20年 12月 15日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1128/MCB.02123-07 (→Scopusで検索)
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| ○PMID (任意): | □ | 19075001 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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| 2. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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