| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 沢津橋 俊 ([徳島大学.先端酵素学研究所.技術開発支援部門])
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| 2. | (英) Murata Takuya (日) (読)
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| 3. | (英) Lim Jinseon (日) (読)
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| 4. | (英) Fujiki Ryoji (日) (読)
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| 5. | (英) Ito Saya (日) (読)
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| 6. | (英) Suzuki Eriko (日) (読)
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| 7. | (英) Tanabe Masahiko (日) (読)
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| 8. | (英) Zhao Yue (日) (読)
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| 9. | (英) Kimura Shuhei (日) (読)
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| 10. | (英) Fujiyama Sally (日) (読)
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| 11. | (英) Ueda Takashi (日) (読)
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| 12. | (英) Umetsu Daiki (日) (読)
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| 13. | (英) Ito Takashi (日) (読)
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| 14. | (英) Takeyama Ken-ichi (日) (読)
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| 15. | (英) Kato Shigeaki (日) (読)
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| ○題名 (必須): | □ | (英) A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor. (日)
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| ○要約 (任意): | □ | (英) Chromatin reorganization is essential for transcriptional control by sequence-specific transcription factors. However, the molecular link between transcriptional control and chromatin reconfiguration remains unclear. By colocalization of the nuclear ecdysone receptor (EcR) on the ecdysone-induced puff in the salivary gland, Drosophila DEK (dDEK) was genetically identified as a coactivator of EcR in both insect cells and intact flies. Biochemical purification and characterization of the complexes containing fly and human DEKs revealed that DEKs serve as histone chaperones via phosphorylation by forming complexes with casein kinase 2. Consistent with the preferential association of the DEK complex with histones enriched in active epigenetic marks, dDEK facilitated H3.3 assembly during puff formation. In some human myeloid leukemia patients, DEK was fused to CAN by chromosomal translocation. This mutation significantly reduced formation of the DEK complex, which is required for histone chaperone activity. Thus, the present study suggests that at least one histone chaperone can be categorized as a type of transcriptional coactivator for nuclear receptors. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Chromatin (日) (読)
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| 3. | (英) Chromosomal Proteins, Non-Histone (日) (読)
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| 4. | (英) Conserved Sequence (日) (読)
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| 5. | (英) Drosophila Proteins (日) (読)
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| 6. | (英) Drosophila melanogaster (日) (読)
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| 7. | (英) Ecdysone (日) (読)
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| 8. | (英) Evolution, Molecular (日) (読)
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| 9. | (英) Histone Chaperones (日) (読)
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| 10. | (英) Humans (日) (読)
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| 11. | (英) Leukemia, Myeloid, Acute (日) (読)
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| 12. | (英) Nucleosomes (日) (読)
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| 13. | (英) Oncogene Proteins (日) (読)
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| 14. | (英) Poly-ADP-Ribose Binding Proteins (日) (読)
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| 15. | (英) Receptors, Cytoplasmic and Nuclear (日) (読)
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| 16. | (英) Receptors, Eph Family (日) (読)
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| 17. | (英) Transcriptional Activation (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Genes & Development (Cold Spring Harbor Laboratory Press)
(pISSN: 0890-9369, eISSN: 1549-5477)
| ○ISSN (任意): | □ | 1549-5477
ISSN: 0890-9369
(pISSN: 0890-9369, eISSN: 1549-5477) Title: Genes & developmentTitle(ISO): Genes DevPublisher: Cold Spring Harbor Laboratory Press (NLM Catalog)
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| ○巻 (必須): | □ | 24
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 159 170
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2009年 12月 29日 (平成 21年 12月 29日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1101/gad.1857410 (→Scopusで検索)
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| ○PMID (任意): | □ | 20040570 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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| 2. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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