『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 学内共著 (徳島大学内研究者との共同研究 (学外研究者を含まない)) [継承]
学究種別 (推奨):
組織 (推奨): 1.徳島大学.生物資源産業学部.生物資源産業学科.食料科学講座 (2016年4月1日〜) [継承]
著者 (必須): 1. (英) Nishimura-Danjobara Yumiko (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Oyama Keisuke (日) (読)
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学籍番号 (推奨):
[継承]
3.金丸 芳 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.食料科学系.食料科学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.食料科学講座])
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Takahashi Keiko (日) (読)
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学籍番号 (推奨):
[継承]
5.横井川 久己男
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学籍番号 (推奨):
[継承]
6.小山 保夫
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) N-(3-oxododecanoyl)-L-homoserine-lactone, a quorum sensing molecule, affects cellular content of nonprotein thiol content in rat lymphocytes: Its relation with intracellular Zn2+  (日)    [継承]
副題 (任意):
要約 (任意): (英) Cellular actions of N-(3-oxododecanoyl)-L-homoserine-lactone (ODHL), a quorum sensing molecule of bacteria, were studied on rat thymocytes using a flow cytometer with appropriate fluorescent dyes to elucidate the effects of ODHL on host cells. A bell-shaped concentration-response relation was observed in the ODHL-induced changes in cellular glutathione content ([GSH]i). ODHL concentration-dependently increased intracellular Zn2+ levels ([Zn2+]i) and cellular O2- content ([O2-]i). The bell-shaped relation induced by ODHL can be explained as follows: a low concentration of ODHL is expected to induce moderate oxidative stress that intracellularly releases Zn2+ by converting thiols to disulfides. A slight elevation of [Zn2+]i may increase the [GSH]i. On the other hand, it is likely that a high concentration of ODHL causes severe oxidative stress that further causes both the decrease in [GSH]i and the increase in [Zn2+]i. Excessive increase in [Zn2+]i may augment oxidative stress that further decreases the [GSH]i. Other notable actions induced by ODHL included the elevation of [Zn2+]i by Zn2+ influx and the increase in [GSH]i under Zn2+-free conditions. Therefore, it is suggested that ODHL elicits diverse actions on host cells.  (日)    [継承]
キーワード (推奨): 1. (英) 4-Butyrolactone (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Apoptosis (日) (読) [継承]
4. (英) Cells, Cultured (日) (読) [継承]
5. (英) Glutathione (日) (読) [継承]
6. (英) Homoserine (日) (読) [継承]
7. (英) Lymphocytes (日) (読) [継承]
8. (英) Male (日) (読) [継承]
9. (英) Oxidative Stress (日) (読) [継承]
10. (英) Quorum Sensing (日) (読) [継承]
11. (英) Rats (日) (読) [継承]
12. (英) Rats, Wistar (日) (読) [継承]
13. (英) Sulfhydryl Compounds (日) (読) [継承]
14. (英) Thymus Gland (日) (読) [継承]
15. (英) Zinc (日) (読) [継承]
発行所 (推奨): Elsevier (->組織[Elsevier Science]) [継承]
誌名 (必須): Chemico-Biological Interactions ([Elsevier Science])
(pISSN: 0009-2797, eISSN: 1872-7786)

ISSN (任意): 1872-7786
ISSN: 0009-2797 (pISSN: 0009-2797, eISSN: 1872-7786)
Title: Chemico-biological interactions
Title(ISO): Chem Biol Interact
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 280 [継承]
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都市 (任意): アムステルダム (Amsterdam/[オランダ王国]) [継承]
年月日 (必須): 西暦 2018年 1月 25日 (平成 30年 1月 25日) [継承]
URL (任意): http://www.sciencedirect.com/science/article/pii/S0009279717312711 [継承]
DOI (任意): 10.1016/j.cbi.2017.12.013    (→Scopusで検索) [継承]
PMID (任意): 29223568    (→Scopusで検索) [継承]
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機関リポジトリ : 111976 [継承]
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備考 (任意): 1.(英) Article.ELocationID: S0009-2797(17)31271-1  (日)    [継承]
2.(英) Article.ELocationID: 10.1016/j.cbi.2017.12.013  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) KeywordList.Keyword: Glutathione  (日)    [継承]
5.(英) KeywordList.Keyword: Intracellular Zn(2+) levels  (日)    [継承]
6.(英) KeywordList.Keyword: Lymphocytes  (日)    [継承]
7.(英) KeywordList.Keyword: N-(3-oxododecanoyl)-l-homoserine-lactone  (日)    [継承]
8.(英) KeywordList.Keyword: Oxidative stress  (日)    [継承]
9.(英) KeywordList.Keyword: Quorum sensing molecule  (日)    [継承]

標準的な表示

和文冊子 ● Yumiko Nishimura-Danjobara, Keisuke Oyama, Kaori Kanemaru, Keiko Takahashi, Kumio Yokoigawa and Yasuo Oyama : N-(3-oxododecanoyl)-L-homoserine-lactone, a quorum sensing molecule, affects cellular content of nonprotein thiol content in rat lymphocytes: Its relation with intracellular Zn2+, Chemico-Biological Interactions, Vol.280, 28-32, 2018.
欧文冊子 ● Yumiko Nishimura-Danjobara, Keisuke Oyama, Kaori Kanemaru, Keiko Takahashi, Kumio Yokoigawa and Yasuo Oyama : N-(3-oxododecanoyl)-L-homoserine-lactone, a quorum sensing molecule, affects cellular content of nonprotein thiol content in rat lymphocytes: Its relation with intracellular Zn2+, Chemico-Biological Interactions, Vol.280, 28-32, 2018.

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