| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○著者 (必須): | 1. | (英) Saito Yasuyuki (日) (読)
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| 2. | (英) Respatika Datu (日) (読)
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| 3. | (英) Komori Satomi (日) (読)
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| 4. | (英) Washio Ken (日) (読)
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| 5. | (英) Nishimura Taichi (日) (読)
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| 6. | (英) Kotani Takenori (日) (読)
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| 7. | (英) Murata Yoji (日) (読)
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| 8. | (英) Okazawa Hideki (日) (読)
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| 9. | (英) Ohnishi Hiroshi (日) (読)
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| 10. | (英) Kaneko Yoriaki (日) (読)
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| 11. | (英) Yui Katsuyuki (日) (読)
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| 12. | 安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| 13. | (英) Nishigori Chikako (日) (読)
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| 14. | (英) Nojima Yoshihisa (日) (読)
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| 15. | (英) Matozaki Takashi (日) (読)
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| ○題名 (必須): | □ | (英) SIRP(+) dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the adult spleen. (日)
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| ○要約 (任意): | □ | (英) In secondary lymphoid organs, development and homeostasis of stromal cells such as podoplanin (Pdpn)-positive fibroblastic reticular cells (FRCs) are regulated by hematopoietic cells, but the cellular and molecular mechanisms of such regulation have remained unclear. Here we show that ablation of either signal regulatory protein (SIRP), an Ig superfamily protein, or its ligand CD47 in conventional dendritic cells (cDCs) markedly reduced the number of CD4(+) cDCs as well as that of Pdpn(+) FRCs and T cells in the adult mouse spleen. Such ablation also impaired the survival of FRCs as well as the production by CD4(+) cDCs of tumor necrosis factor receptor (TNFR) ligands, including TNF-, which was shown to promote the proliferation and survival of Pdpn(+) FRCs. CD4(+) cDCs thus regulate the steady-state homeostasis of FRCs in the adult spleen via the production of TNFR ligands, with the CD47-SIRP interaction in cDCs likely being indispensable for such regulation. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Proceedings of the National Academy of Sciences of the United States of America ([The National Academy of Sciences of the United States of America])
(pISSN: 0027-8424, eISSN: 1091-6490)
| ○ISSN (任意): | □ | 1091-6490
ISSN: 0027-8424
(pISSN: 0027-8424, eISSN: 1091-6490) Title: Proceedings of the National Academy of Sciences of the United States of AmericaTitle(ISO): Proc Natl Acad Sci U S APublisher: National Academy of Sciences (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 114
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| ○号 (必須): | □ | 47
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| ○頁 (必須): | □ | E10151 E10160
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2017年 11月 6日 (平成 29年 11月 6日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1073/pnas.1711345114 (→Scopusで検索)
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| ○PMID (任意): | □ | 29109283 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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