『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=334512EID:334512, Map:0, LastModified:2018年5月17日(木) 15:55:07, Operator:[田中 栄二], Avail:TRUE, Censor:0, Owner:[田中 栄二], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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学究種別 (推奨): 博士課程学生による研究報告 [継承]
組織 (推奨): 1.徳島大学.口腔科学教育部.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学 (2004年4月1日〜) [継承]
2.徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学 (2015年4月1日〜) [継承]
3.徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.生体栄養学 (2015年4月1日〜) [継承]
著者 (必須): 1.BAYARSAIKHAN ODO ([徳島大学.口腔科学教育部.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
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学籍番号 (推奨): **** [ユーザ]
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2.川合 暢彦
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3.森 博世
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4.木内 奈央
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5.二川 健 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.生体栄養学])
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6.田中 栄二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学])
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題名 (必須): (英) Co-Administration of Myostatin-Targeting siRNA and ActRIIB-Fc Fusion Protein Increases Masseter Muscle Mass and Fiber Size.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Myostatin, a member of the TGF- superfamily, is a negative regulator of skeletal muscle cell growth and differentiation, and binds with high affinity to the activin type IIB receptor (ActRIIB). The soluble ligand-binding domain of ActRIIB fused to the Fc domain of IgG (ActRIIB-Fc) potently binds and inhibits TGF- family members in muscle, leading to rapid and marked muscle growth. The present study was designed to assess the effectiveness of the co-delivery of myostatin-targeting siRNA (Mstn-siRNA) and ActRIIB-Fc into skeletal muscle as a potential treatment of atrophic myopathies. Eleven-week-old, male C57BL/6 mice were injected with atelocollagen (ATCOL)-mediated Mstn-siRNA with/without ActRIIB-Fc locally into the masseter muscle twice a week. Inhibition of myostatin function by the combination of Mstn-siRNA and ActRIIB-Fc increased muscle weight and myofibril size in murine masseter muscle. Real-time RT-PCR analysis revealed significant downregulation of myostatin mRNA expression in both the Mstn-siRNA-treated and the combination treatment group. Furthermore, myogenin mRNA expression was upregulated in the combination treatment group, while MuRF-1 and Atrogin-1 mRNA expression was downregulated compared to administration of each compound alone. These findings suggest that double inhibition of myostatin is a potentially useful treatment strategy to increase muscle mass and fiber size and could be a useful treatment of patients with various muscle atrophies, including muscular dystrophy.  (日)    [継承]
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誌名 (必須): Journal of Nutritional Science and Vitaminology ([日本栄養·食糧学会]/[日本ビタミン学会])
(pISSN: 0301-4800, eISSN: 1881-7742)

ISSN (任意): 1881-7742
ISSN: 0301-4800 (pISSN: 0301-4800, eISSN: 1881-7742)
Title: Journal of nutritional science and vitaminology
Title(ISO): J Nutr Sci Vitaminol (Tokyo)
Supplier: 日本ビタミン学会
Publisher: Center for Academic Publications Japan
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2017年 0月 初日 (平成 29年 0月 初日) [継承]
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DOI (任意): 10.3177/jnsv.63.244    (→Scopusで検索) [継承]
PMID (任意): 28978871    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日) 8. Bayarsaikhan Od, Kawai N, Mori H, Kinouchi N, Nikawa T, Tanaka E* (2017). Co-administration of myostatin-targeting siRNA and ActRIIB-Fc fusion protein increases masseter muscle mass and fiber size. Journal of Nutritional Science and Vitaminology 63(4):244-248, Oct. PMID: 28978871   [継承]

標準的な表示

和文冊子 ● ODO BAYARSAIKHAN, Nobuhiko Kawai, Hiroyo Mori, Nao Kinouchi, Takeshi Nikawa and Eiji Tanaka : Co-Administration of Myostatin-Targeting siRNA and ActRIIB-Fc Fusion Protein Increases Masseter Muscle Mass and Fiber Size., Journal of Nutritional Science and Vitaminology, Vol.63, No.4, 244-248, 2017.
欧文冊子 ● ODO BAYARSAIKHAN, Nobuhiko Kawai, Hiroyo Mori, Nao Kinouchi, Takeshi Nikawa and Eiji Tanaka : Co-Administration of Myostatin-Targeting siRNA and ActRIIB-Fc Fusion Protein Increases Masseter Muscle Mass and Fiber Size., Journal of Nutritional Science and Vitaminology, Vol.63, No.4, 244-248, 2017.

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