『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=333772EID:333772, Map:0, LastModified:2018年12月2日(日) 21:58:06, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[小山 保夫], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) [継承]
学究種別 (推奨):
組織 (推奨): 1.徳島大学.生物資源産業学部.生物資源産業学科.食料科学講座 (2016年4月1日〜) [継承]
著者 (必須): 1.亀村 典生 ([徳島大学.先端酵素学研究所])
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2. (英) Oyama Keisuke (日) (読)
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3.金丸 芳 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.食料科学系.食料科学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.食料科学講座])
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4.横井川 久己男
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5.小山 保夫
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題名 (必須): (英) Diverse cellular actions of tert-butylhydroquinone, a food additive, on rat thymocytes  (日)    [継承]
副題 (任意):
要約 (任意): (英) Tertiary butylhydroquinone (TBHQ) is a food additive that possesses antioxidant activity. Its alternative applications have been explored in recent studies. However, there is controversy regarding safety. In this study using rat thymocytes, the cellular actions of TBHQ at sublethal concentrations were examined. TBHQ at concentrations of 3 µM or more elevated intracellular Zn2+ concentration ([Zn2+]i) in a dose-dependent manner, by increasing membrane Zn2+ permeability and releasing Zn2+ from cellular stores. TBHQ at 30 µM significantly increased side scatter (cell density) and the exposure of phosphatidylserine (PS) on cell membrane surfaces. It also decreased cellular glutathione (GSH) content without affecting cell lethality. Forward scatter was attenuated by 100 µM TBHQ. Thus, it is considered that TBHQ at sublethal concentrations (30 µM or less) exerts some adverse actions on cells. TBHQ at 10 30 µM attenuated the increase in cell lethality induced by hydrogen peroxide (H2O2), while potentiation of H2O2 cytotoxicity by 100 µM TBHQ was observed. The range of concentrations of TBHQ from benefit to toxicity under in vitro conditions may be 10 30 µM. Although TBHQ exhibits antioxidative actions at concentrations that are lower than those which elicit adverse cellular effects, sublethal levels of TBHQ cause some adverse actions that may be clinically concerned.  (日)    [継承]
キーワード (推奨): 1. (英) food additive (日) (読) [継承]
発行所 (推奨): Elsevier Science [継承]
誌名 (必須): Toxicology Research ([英国王立化学会])
(pISSN: 2045-452X, eISSN: 2045-4538)

ISSN (任意): 2045-4538
ISSN: 2045-452X (pISSN: 2045-452X, eISSN: 2045-4538)
Title: Toxicology research
Title(ISO): Toxicol Res (Camb)
Publisher: Royal Society of Chemistry
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 922 929 [継承]
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年月日 (必須): 西暦 2017年 12月 初日 (平成 29年 12月 初日) [継承]
URL (任意): http://pubs.rsc.org/-/content/articlelanding/2017/tx/c7tx00183e/unauth#!divAbstract [継承]
DOI (任意): 10.1039/C7TX00183E    (→Scopusで検索) [継承]
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機関リポジトリ : 111981 [継承]
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標準的な表示

和文冊子 ● Norio Kamemura, Keisuke Oyama, Kaori Kanemaru, Kumio Yokoigawa and Yasuo Oyama : Diverse cellular actions of tert-butylhydroquinone, a food additive, on rat thymocytes, Toxicology Research, Vol.6, 922-929, 2017.
欧文冊子 ● Norio Kamemura, Keisuke Oyama, Kaori Kanemaru, Kumio Yokoigawa and Yasuo Oyama : Diverse cellular actions of tert-butylhydroquinone, a food additive, on rat thymocytes, Toxicology Research, Vol.6, 922-929, 2017.

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