『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=332558EID:332558, Map:0, LastModified:2017年8月28日(月) 18:49:59, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[堤 理恵], Read:継承, Write:継承, Delete:継承.
種別 (必須):
言語 (必須): 英語 [継承]
招待 (推奨):
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カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Venkatesh Thejaswini (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Suresh S. Padmanaban (日) (読)
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学籍番号 (推奨):
[継承]
3.堤 理恵 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.代謝栄養学])
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学籍番号 (推奨):
[継承]
題名 (必須): (英) tRFs: miRNAs in disguise.  (日)    [継承]
副題 (任意):
要約 (任意): (英) tRFs and tiRNAs are two new classes of regulatory non-coding small RNAs that are derived from the cleavage of pre-existing tRNAs. tRFs are 18-22 nt long and are classified into the tRF-5, tRF-3, and tRF-1 series. Here, we discuss in detail the regulatory roles of tRFs in translation, viral infections, and carcinogenesis. Moreover, we have reviewed the association of tRFs with Argonaute proteins, including their potential to function as miRNAs. Interestingly, few miRNAs are generated from pre-existing tRNAs. Hence, tRNAs generate similar-sized tRFs and miRNAs, leading to misannotations due to cross mapping of tRFs and tRNA-derived miRNAs during deep sequencing data analysis. Therefore, it is important to catalogue the overlapping sequences between tRNA-derived miRNAs and tRFs. We have catalogued the miRNAs that overlap with tRFs sequences in humans using miRBase. We identified 20 tRNA-derived miRNAs that share sequences with tRFs. Of the 20 miRNAs, 5 miRNAs (miR-3182, miR-4521, miR-1260a, miR-1260b, and miR-7977) showed significant prediction scores. Furthermore, we have identified a lysine degradation pathway as a common regulatory pathway for miR-1260a, miR-1260b, and miR-3182 by using DIANA-mirPath.  (日)    [継承]
キーワード (推奨): 1. (英) Argonaute Proteins (日) (読) [継承]
2. (英) High-Throughput Nucleotide Sequencing (日) (読) [継承]
3. (英) Humans (日) (読) [継承]
4. (英) MicroRNAs (日) (読) [継承]
5. (英) Protein Binding (日) (読) [継承]
6. (英) Protein Biosynthesis (日) (読) [継承]
7. (英) RNA, Transfer (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Gene ([Elsevier Science B.V.])
(pISSN: 0378-1119, eISSN: 1879-0038)

ISSN (任意): 1879-0038
ISSN: 0378-1119 (pISSN: 0378-1119, eISSN: 1879-0038)
Title: Gene
Title(ISO): Gene
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 579 [継承]
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(必須): 133 138 [継承]
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年月日 (必須): 西暦 2015年 12月 29日 (平成 27年 12月 29日) [継承]
URL (任意):
DOI (任意): 10.1016/j.gene.2015.12.058    (→Scopusで検索) [継承]
PMID (任意): 26743126    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1016/j.gene.2015.12.058  (日)    [継承]
2.(英) Article.ELocationID: S0378-1119(15)01570-X  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Review  (日)    [継承]
5.(英) KeywordList.Keyword: miRNAs  (日)    [継承]
6.(英) KeywordList.Keyword: tRFs  (日)    [継承]
7.(英) KeywordList.Keyword: tRNAs  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : Thejaswini Venkatesh, Padmanaban S. Suresh and Rie Tsutsumi : tRFs: miRNAs in disguise., Gene, Vol.579, No.2, 133-138, (発行所), (都市), Dec. 2015.
欧文冊子 ● (種別) : Thejaswini Venkatesh, Padmanaban S. Suresh and Rie Tsutsumi : tRFs: miRNAs in disguise., Gene, Vol.579, No.2, 133-138, (発行所), (都市), Dec. 2015.

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