| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Yoshiro Nishimura (日) (読)
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| 2. | (英) Masaaki Ueki (日) (読)
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| 3. | 今西 正樹 ([徳島大学.大学院医歯薬学研究部.薬学域.先端薬学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品機能生化学])
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| 4. | 冨田 修平
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| 5. | (英) Masaki Ueno (日) (読)
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| 6. | (英) Jun Morishita (日) (読)
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| 7. | (英) Takashi Nishiyama (日) (読)
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| ○題名 (必須): | □ | (英) Reoxygenation With 100% Oxygen Following Hypoxia in Mice Causes Apoptosis (日)
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| ○要約 (任意): | □ | (英) After hypoxia, reoxygenation with air is the consensus treatment for full-term neonates; however, the effect of hyperoxic reoxygenation of adults is unknown. The present study was designed to investigate the effects of reoxygenation with 100% oxygen after hypoxia on inflammation and apoptosis in mice. Eight-week-old mice were either subjected to hypoxia in 8% oxygen for 30 min or air served as controls. Following hypoxia, mice underwent reoxygenation for 30 min with 21% or 100% oxygen. Tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), caspase-3 and brain derived neurotrophic factor (BDNF) mRNA study and histopathological study were performed. Reoxygenation with 100% oxygen significantly increased TNF-α (2.5 h after hypoxia), IL-1β (5 h after hypoxia), caspase-3 (8 h after hypoxia) mRNA levels in the whole brain compared with 21% oxygen, and significantly decreased erythropoietin mRNA expression compared with 21% oxygen 9 h after reoxygenation. However, reoxygenation with 100% oxygen and 21% oxygen significantly decreased BDNF mRNA levels compared with control air group. There were no clear abnormal findings showing neuronal death among the three groups. Reoxygenation with 100% oxygen after hypoxia induced inflammation and apoptosis in adult mice. Therefore, these results suggest that the reoxygenation with 100% oxygen after hypoxia has harmful effects on adult brain as well as on neonatal brain. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | アポトーシス (apoptosis)
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| 3. | (英) Brain-Derived Neurotrophic Factor (日) (読)
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| 4. | (英) Caspase 3 (日) (読)
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| 5. | (英) Erythropoietin (日) (読)
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| 6. | (英) Hypoxia (日) (読)
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| 7. | (英) Interleukin-1 (日) (読)
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| 8. | (英) Male (日) (読)
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| 9. | (英) Mice (日) (読)
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| 10. | (英) Mice, Inbred C57BL (日) (読)
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| 11. | (英) Oxygen (日) (読)
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| 12. | (英) RNA, Messenger (日) (読)
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| 13. | (英) Tumor Necrosis Factor-alpha (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Shock (Shock Society/European Shock Society/Brazilian Shock Society/International Federation of Shock Societies/Indonesian Shock Society/Japan Shock Society)
(pISSN: 1073-2322, eISSN: 1540-0514)
| ○ISSN (任意): | □ | 1540-0514
ISSN: 1073-2322
(pISSN: 1073-2322, eISSN: 1540-0514) Title: Shock (Augusta, Ga.)Title(ISO): ShockPublisher: Lippincott Williams and Wilkins (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 48
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 590 594
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2017年 11月 初日 (平成 29年 11月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1097/SHK.0000000000000891 (→Scopusで検索)
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| ○PMID (任意): | □ | 28472013 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-85030762981
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1097/SHK.0000000000000891 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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