| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Otani T (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | (英) Ogura Y (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Misaki K (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | (英) Maeda T (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | (英) Kimpara A (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | (英) Yonemura S (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | (英) Hayashi S. (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | 米村 重信 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.細胞生物学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) IKK inhibits PKC to promote Fascin-dependent actin bundling. (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Signaling molecules have pleiotropic functions and are activated by various extracellular stimuli. Protein kinase C (PKC) is activated by diverse receptors, and its dysregulation is associated with diseases including cancer. However, how the undesired activation of PKC is prevented during development remains poorly understood. We have previously shown that a protein kinase, IKKϵ, is active at the growing bristle tip and regulates actin bundle organization during Drosophila bristle morphogenesis. Here, we demonstrate that IKKϵ regulates the actin bundle localization of a dynamic actin cross-linker, Fascin. IKKϵ inhibits PKC, thereby protecting Fascin from inhibitory phosphorylation. Excess PKC activation is responsible for the actin bundle defects in IKKϵ-deficient bristles, whereas PKC is dispensable for bristle morphogenesis in wild-type bristles, indicating that PKC is repressed by IKKϵ in wild-type bristle cells. These results suggest that IKKϵ prevents excess activation of PKC during bristle morphogenesis. (日)
| [継承] |
| ○キーワード (推奨): | 1. | (英) Actins (日) (読)
| [継承] |
| 2. | (英) Animals (日) (読)
| [継承] |
| 3. | (英) Carrier Proteins (日) (読)
| [継承] |
| 4. | (英) Drosophila (日) (読)
| [継承] |
| 5. | (英) Drosophila Proteins (日) (読)
| [継承] |
| 6. | (英) I-kappa B Kinase (日) (読)
| [継承] |
| 7. | (英) Microfilament Proteins (日) (読)
| [継承] |
| 8. | (英) Phosphorylation (日) (読)
| [継承] |
| 9. | (英) Protein Kinase C (日) (読)
| [継承] |
| 10. | (英) Signal Transduction (日) (読)
| [継承] |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Development ([The Company of Biologists Limited])
(pISSN: 0950-1991, eISSN: 1477-9129)
| ○ISSN (任意): | □ | 1477-9129
ISSN: 0950-1991
(pISSN: 0950-1991, eISSN: 1477-9129) Title: Development (Cambridge, England)Title(ISO): DevelopmentPublisher: Company of Biologists (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 143
| [継承] |
| ○号 (必須): | □ | 20
| [継承] |
| ○頁 (必須): | □ | 3806 3816
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 10月 15日 (平成 28年 10月 15日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.1242/dev.138495 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 27578797 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
| [継承] |
| 2. | (英) KeywordList.Keyword: Actin (日)
| [継承] |
| 3. | (英) KeywordList.Keyword: Bristle morphogenesis (日)
| [継承] |
| 4. | (英) KeywordList.Keyword: Drosophila (日)
| [継承] |
| 5. | (英) KeywordList.Keyword: Fascin (日)
| [継承] |
| 6. | (英) KeywordList.Keyword: IKKϵ (日)
| [継承] |
| 7. | (英) KeywordList.Keyword: PKC (日)
| [継承] |
| 8. | (英) KeywordList.Keyword: Singed (日)
| [継承] |
| 9. | (英) CoiStatement: The authors declare no competing or financial interests. (日)
| [継承] |