| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Shibata N (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | (英) Kashima M (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Ishiko T (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | (英) Nishimura O (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | (英) Rouhana L (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | (英) Misaki K (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | (英) Yonemura S (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | (英) Saito K (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 9. | (英) Siomi H (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 10. | (英) Siomi MC (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 11. | (英) Agata K. (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 12. | 米村 重信 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.細胞生物学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Inheritance of a Nuclear PIWI from Pluripotent Stem Cells by Somatic Descendants Ensures Differentiation by Silencing Transposons in Planarian. (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Differentiation of pluripotent stem cells (PSCs) requires transposon silencing throughout the process. PIWIs, best known as key factors in germline transposon silencing, are also known to act in somatic differentiation of planarian PSCs (neoblasts). However, how PIWIs control the latter process remains elusive. Here, using Dugesia japonica, we show that a nuclear PIWI, DjPiwiB, was bound to PIWI-interacting RNAs (generally key mediators of PIWI-dependent transposon silencing), and was detected in not only neoblasts but also their descendant somatic cells, which do not express piwi. In contrast, cytoplasmic DjPiwiA and DjPiwiC were detected only in neoblasts, in accord with their transcription there. DjPiwiB was indispensable for regeneration, but dispensable for transposon silencing in neoblasts. However, transposons were derepressed at the onset of differentiation in DjPiwiB-knockdown planarians. Thus, DjPiwiB appears to be inherited by descendant somatic cells of neoblasts to ensure transposon silencing in those cells, which are unable to produce PIWI proteins. (日)
| [継承] |
| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
| [継承] |
| 2. | (英) Argonaute Proteins (日) (読)
| [継承] |
| 3. | (英) Base Sequence (日) (読)
| [継承] |
| 4. | (英) Cell Differentiation (日) (読)
| [継承] |
| 5. | (英) Cell Nucleus (日) (読)
| [継承] |
| 6. | (英) DNA Transposable Elements (日) (読)
| [継承] |
| 7. | (英) Gene Silencing (日) (読)
| [継承] |
| 8. | (英) Immunohistochemistry (日) (読)
| [継承] |
| 9. | (英) Inheritance Patterns (日) (読)
| [継承] |
| 10. | (英) Models, Biological (日) (読)
| [継承] |
| 11. | (英) Planarians (日) (読)
| [継承] |
| 12. | (英) Pluripotent Stem Cells (日) (読)
| [継承] |
| 13. | (英) RNA, Small Interfering (日) (読)
| [継承] |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Developmental Cell (Cell Press)
(pISSN: 1534-5807, eISSN: 1878-1551)
| ○ISSN (任意): | □ | 1878-1551
ISSN: 1534-5807
(pISSN: 1534-5807, eISSN: 1878-1551) Title: Developmental cellTitle(ISO): Dev CellPublisher: Cell Press (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 37
| [継承] |
| ○号 (必須): | □ | 3
| [継承] |
| ○頁 (必須): | □ | 226 237
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 5月 9日 (平成 28年 5月 9日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.devcel.2016.04.009 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 27165555 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.devcel.2016.04.009 (日)
| [継承] |
| 2. | (英) Article.ELocationID: S1534-5807(16)30229-5 (日)
| [継承] |
| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
| [継承] |