| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Higashiguchi Y (日) (読)
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| 2. | (英) Katsuta K (日) (読)
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| 3. | (英) Minegishi T (日) (読)
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| 4. | (英) Yonemura S (日) (読)
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| 5. | (英) Urasaki A (日) (読)
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| 6. | (英) Inagaki N. (日) (読)
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| 7. | 米村 重信 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.細胞生物学])
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| ○題名 (必須): | □ | (英) Identification of a shootin1 isoform expressed in peripheral tissues. (日)
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| ○要約 (任意): | □ | (英) Shootin1 is a brain-specific cytoplasmic protein involved in neuronal polarity formation and axon outgrowth. It accumulates at the leading edge of axonal growth cones, where it mediates the mechanical coupling between F-actin retrograde flow and cell adhesions as a clutch molecule, thereby producing force for axon outgrowth. In this study, we report a novel splicing isoform of shootin1 which is expressed not only in the brain but also in peripheral tissues. We have renamed the brain-specific shootin1 as shootin1a and termed the novel isoform as shootin1b. Immunoblot and immunohistochemical analyses with a shootin1b-specific antibody revealed that shootin1b is distributed in various mouse tissues including the lung, liver, stomach, intestines, spleen, pancreas, kidney and skin. Interestingly, shootin1b immunoreactivity was widely detected in epithelial cells that constitute simple and stratified epithelia; in some cells, it colocalized with E-cadherin and cortactin at cell-cell contact sites. Shootin1b also localized in dendritic cells in the spleen. These results suggest that shootin1b may function in various peripheral tissues including epithelial cells. (日)
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| ○キーワード (推奨): | 1. | (英) Aging (日) (読)
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| 2. | (英) Amino Acid Sequence (日) (読)
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| 3. | (英) Animals (日) (読)
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| 4. | (英) Antibody Specificity (日) (読)
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| 5. | (英) Cadherins (日) (読)
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| 6. | (英) Cell Communication (日) (読)
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| 7. | (英) Cortactin (日) (読)
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| 8. | (英) Immunohistochemistry (日) (読)
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| 9. | (英) Mice, Inbred C57BL (日) (読)
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| 10. | (英) Nerve Tissue Proteins (日) (読)
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| 11. | (英) Organ Specificity (日) (読)
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| 12. | (英) Protein Isoforms (日) (読)
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| 13. | (英) Protein Transport (日) (読)
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| 14. | (英) Rats (日) (読)
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| 15. | (英) Tissue Distribution (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Cell and Tissue Research ([Springer-Verlag])
(pISSN: 0302-766X, eISSN: 1432-0878)
| ○ISSN (任意): | □ | 1432-0878
ISSN: 0302-766X
(pISSN: 0302-766X, eISSN: 1432-0878) Title: Cell and tissue researchTitle(ISO): Cell Tissue ResSupplier: Springer Online Journal ArchivePublisher: Springer (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 366
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 75 87
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 5月 13日 (平成 28年 5月 13日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s00441-016-2415-9 (→Scopusで検索)
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| ○PMID (任意): | □ | 27177867 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1007/s00441-016-2415-9 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Clutch molecule (日)
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| 4. | (英) KeywordList.Keyword: Dendritic cell (日)
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| 5. | (英) KeywordList.Keyword: Epithelial cell (日)
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| 6. | (英) KeywordList.Keyword: Shootin1b (日)
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