| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 六車 直樹
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| 2. | 岡本 耕一 ([徳島大学.病院.診療科.内科.消化器内科])
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| 3. | 中川 忠彦
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| 4. | (英) Sannomiya Katsutaka (日) (読)
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| 5. | (英) Fujimoto Shota (日) 藤本 将太 (読) ふじもと しょうた
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| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 6. | 三井 康裕 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| 7. | 木村 哲夫
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| 8. | 宮本 弘志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学]/[徳島大学.病院.診療科.内科.消化器内科])
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| 9. | 東島 潤
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| 10. | 島田 光生
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| 11. | (英) Horino Yoko (日) (読)
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| 12. | (英) Matsumoto Shinya (日) (読)
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| 13. | (英) Hanaoka Kenjiro (日) (読)
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| 14. | (英) Nagano Tetsuo (日) (読)
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| 15. | (英) Shibutani Makoto (日) (読)
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| 16. | 高山 哲治 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| ○題名 (必須): | □ | (英) Molecular imaging of aberrant crypt foci in the human colon targeting glutathione S-transferase P1-1. (日)
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| ○要約 (任意): | □ | (英) Aberrant crypt foci (ACF), the earliest precursor lesion of colorectal cancers (CRCs), are a good surrogate marker for CRC risk stratification and chemoprevention. However, the conventional ACF detection method with dye-spraying by magnifying colonoscopy is labor- and skill-intensive. We sought to identify rat and human ACF using a fluorescent imaging technique that targets a molecule specific for ACF. We found that glutathione S-transferase (GST) P1-1 was overexpressed in ACF tissues in a screening experiment. We then synthesized the fluorogenic probe, DNAT-Me, which is fluorescently quenched but is activated by GSTP1-1. A CRC cell line incubated with DNAT-Me showed strong fluorescence in the cytosol. Fluorescence intensities correlated significantly with GST activities in cancer cell lines. When we sprayed DNAT-Me onto colorectal mucosa excised from azoxymethane-treated rats and surgically resected from CRC patients, ACF with strong fluorescent signals were clearly observed. The ACF number determined by postoperative DNAT-Me imaging was almost identical to that determined by preoperative methylene blue staining. The signal-to-noise ratio for ACF in DNAT-Me images was significantly higher than that in methylene blue staining. Thus, we sensitively visualized ACF on rat and human colorectal mucosa by using a GST-activated fluorogenic probe without dye-spraying and magnifying colonoscopy. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Scientific Reports ([Nature Publishing Group])
(eISSN: 2045-2322)
| ○ISSN (任意): | □ | 2045-2322
ISSN: 2045-2322
(eISSN: 2045-2322) Title: Scientific reportsTitle(ISO): Sci RepPublisher: Nature Portfolio (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 7
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 6536 6536
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2017年 7月 26日 (平成 29年 7月 26日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1038/s41598-017-06857-x (→Scopusで検索)
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| ○PMID (任意): | □ | 28747791 (→Scopusで検索)
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| ○機関リポジトリ : | □ | 112373
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1038/s41598-017-06857-x (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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