『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=330607)

EID=330607EID:330607, Map:0, LastModified:2018年11月29日(木) 11:57:03, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[三宅 雅人], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Taniuchi Shusuke (日) (読)
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2.三宅 雅人 ([徳島大学.先端酵素学研究所.重点研究部門])
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3. (英) Tsugawa Kazue (日) (読)
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4.親泊 美帆 ([徳島大学.先端酵素学研究所.重点研究部門])
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5.親泊 政一 ([徳島大学.先端酵素学研究所.重点研究部門])
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題名 (必須): (英) Integrated stress response of vertebrates is regulated by four eIF2α kinases.  (日)    [継承]
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要約 (任意): (英) The integrated stress response (ISR) is a cytoprotective pathway initiated upon phosphorylation of the eukaryotic translation initiation factor 2 (eIF2α) residue designated serine-51, which is critical for translational control in response to various stress conditions. Four eIF2α kinases, namely heme-regulated inhibitor (HRI), protein kinase R (PKR), PKR-like endoplasmic reticulum kinase, (PERK) and general control non-depressible 2 (GCN2), have been identified thus far, and they are known to be activated by heme depletion, viral infection, endoplasmic reticulum stress, and amino acid starvation, respectively. Because eIF2α is phosphorylated under various stress conditions, the existence of an additional eIF2α kinase has been suggested. To validate the existence of the unidentified eIF2α kinase, we constructed an eIF2α kinase quadruple knockout cells (4KO cells) in which the four known eIF2α kinase genes were deleted using the CRISPR/Cas9-mediated genome editing. Phosphorylation of eIF2α was completely abolished in the 4KO cells by various stress stimulations. Our data suggests that the four known eIF2α kinases are sufficient for ISR and that there are no additional eIF2α kinases in vertebrates.  (日)    [継承]
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誌名 (必須): Scientific Reports ([Nature Publishing Group])
(eISSN: 2045-2322)

ISSN (任意): 2045-2322
ISSN: 2045-2322 (eISSN: 2045-2322)
Title: Scientific reports
Title(ISO): Sci Rep
Publisher: Nature Portfolio
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 6 [継承]
(必須): [継承]
(必須): 32886 32886 [継承]
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年月日 (必須): 西暦 2016年 9月 16日 (平成 28年 9月 16日) [継承]
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DOI (任意): 10.1038/srep32886    (→Scopusで検索) [継承]
PMID (任意): 27633668    (→Scopusで検索) [継承]
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機関リポジトリ : 112371 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1038/srep32886  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) OtherID: PMC5025754  (日)    [継承]

標準的な表示

和文冊子 ● Shusuke Taniuchi, Masato Miyake, Kazue Tsugawa, Miho Oyadomari and Seiichi Oyadomari : Integrated stress response of vertebrates is regulated by four eIF2α kinases., Scientific Reports, Vol.6, 32886, 2016.
欧文冊子 ● Shusuke Taniuchi, Masato Miyake, Kazue Tsugawa, Miho Oyadomari and Seiichi Oyadomari : Integrated stress response of vertebrates is regulated by four eIF2α kinases., Scientific Reports, Vol.6, 32886, 2016.

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