『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=330545)

EID=330545EID:330545, Map:0, LastModified:2017年9月7日(木) 18:18:22, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[森島 真幸], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Ma FangFang (日) (読)
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[継承]
2.髙成 広起 ([徳島大学.ポストLEDフォトニクス研究所])
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Masuda Kimiko (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4.森島 真幸
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[継承]
5. (英) Ono Katsushige (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Short- and long-term inhibition of cardiac inward-rectifier potassium channel current by an antiarrhythmic drug bepridil.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Bepridil is an effective antiarrhythmic drug on supraventricular and ventricular arrhythmias, and inhibitor of calmodulin. Recent investigations have been elucidating that bepridil exerts antiarrhythmic effects through its acute and chronic application for patients. The aim of this study was to identify the efficacy and the potential mechanism of bepridil on the inward-rectifier potassium channel in neonatal rat cardiomyocytes in acute- and long-term conditions. Bepridil inhibited inward-rectifier potassium current (I K1) as a short-term effect with IC50 of 17 μM. Bepridil also reduced I K1 of neonatal cardiomyocytes when applied for 24 h in the culture medium with IC50 of 2.7 μM. Both a calmodulin inhibitor (W-7) and an inhibitor of calmodulin-kinase II (KN93) reduced I K1 when applied for 24 h as a long-term effect in the same fashion, suggesting that the long-term application of bepridil inhibits I K1 more potently than that of the short-term application through the inhibition of calmodulin kinase II pathway in cardiomyocytes.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Animals, Newborn (日) (読) [継承]
3. (英) Anti-Arrhythmia Agents (日) (読) [継承]
4. (英) Benzylamines (日) (読) [継承]
5. (英) Bepridil (日) (読) [継承]
6. (英) Calcium-Calmodulin-Dependent Protein Kinase Type 2 (日) (読) [継承]
7. (英) Calmodulin (日) (読) [継承]
8. (英) Cells, Cultured (日) (読) [継承]
9. (英) Membrane Potentials (日) (読) [継承]
10. (英) Myocytes, Cardiac (日) (読) [継承]
11. (英) Potassium Channel Blockers (日) (読) [継承]
12. (英) Potassium Channels, Inwardly Rectifying (日) (読) [継承]
13. (英) Protein Kinase Inhibitors (日) (読) [継承]
14. (英) Rats, Wistar (日) (読) [継承]
15. (英) Sulfonamides (日) (読) [継承]
16. (英) Time Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Heart and Vessels (Japanese Research Promotion Society for Cardiovascular Diseases)
(pISSN: 0910-8327, eISSN: 1615-2573)

ISSN (任意): 1615-2573
ISSN: 0910-8327 (pISSN: 0910-8327, eISSN: 1615-2573)
Title: Heart and vessels
Title(ISO): Heart Vessels
Supplier: Springer Online Journal Archive
Publisher: Springer
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 31 [継承]
(必須): 7 [継承]
(必須): 1176 1184 [継承]
都市 (任意):
年月日 (必須): 西暦 2016年 7月 初日 (平成 28年 7月 初日) [継承]
URL (任意):
DOI (任意): 10.1007/s00380-015-0762-1    (→Scopusで検索) [継承]
PMID (任意): 26498939    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1007/s00380-015-0762-1  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) KeywordList.Keyword: Bepridil  (日)    [継承]
4.(英) KeywordList.Keyword: Calmodulin  (日)    [継承]
5.(英) KeywordList.Keyword: Inward-rectifier K+ channel  (日)    [継承]
6.(英) KeywordList.Keyword: KN93  (日)    [継承]
7.(英) KeywordList.Keyword: W-7  (日)    [継承]

標準的な表示

和文冊子 ● FangFang Ma, Hiroki Takanari, Kimiko Masuda, Masaki Morishima and Katsushige Ono : Short- and long-term inhibition of cardiac inward-rectifier potassium channel current by an antiarrhythmic drug bepridil., Heart and Vessels, Vol.31, No.7, 1176-1184, 2016.
欧文冊子 ● FangFang Ma, Hiroki Takanari, Kimiko Masuda, Masaki Morishima and Katsushige Ono : Short- and long-term inhibition of cardiac inward-rectifier potassium channel current by an antiarrhythmic drug bepridil., Heart and Vessels, Vol.31, No.7, 1176-1184, 2016.

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