『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=330542)

EID=330542EID:330542, Map:0, LastModified:2017年12月12日(火) 14:21:00, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[森島 真幸], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 徳島大学以外での国内共著 (徳島大学以外でのある一つの国に属する複数機関による共同研究 (国外研究者を含まない)) [継承]
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.森島 真幸
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Iwata Eriko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Nakada Chisato (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Tsukamoto Yoshiyuki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.髙成 広起 ([徳島大学.ポストLEDフォトニクス研究所])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Miyamoto Shinji (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Moriyama Masatsugu (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Ono Katsushige (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Atrial Fibrillation-Mediated Upregulation of miR-30d Regulates Myocardial Electrical Remodeling of the G-Protein-Gated K(+) Channel, IK.ACh.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Atrial fibrillation (AF) begets AF in part due to atrial remodeling, the molecular mechanisms of which have not been completely elucidated. This study was conducted to identify microRNA(s) responsible for electrical remodeling in AF. The expression profiles of 1205 microRNAs, in cardiomyocytes from patients with persistent AF and from age-, gender-, and cardiac function-matched control patients with normal sinus rhythm, were examined by use of a microRNA microarray platform. Thirty-nine microRNAs differentially expressed in AF patients' atria were identified, including miR-30d, as a candidate responsible for ion channel remodeling by in silico analysis. MiR-30d was significantly upregulated in cardiomyocytes from AF patients, whereas the mRNA and protein levels ofCACNA1C/Cav1.2 andKCNJ3/Kir3.1, postulated targets of miR-30d, were markedly reduced.KCNJ3/Kir3.1 expression was downregulated by transfection of the miR-30 precursor, concomitant with a reduction of the acetylcholine-sensitive inward-rectifier K(+)current (IK.ACh).KCNJ3/Kir3.1 (but notCACNA1C/Cav1.2) expression was enhanced by the knockdown of miR-30d. The Ca(2+)ionophore, A23187, induced a dose-dependent upregulation of miR-30d, followed by the suppression ofKCNJ3mRNA expression. Blockade of protein kinase C signaling blunted the [Ca(2+)]i-dependent downregulation of Kir3.1 via miR-30d. The downward remodeling ofIK.AChis attributed, at least in part, to deranged Ca(2+)handling, leading to the upregulation of miR-30d in human AF, revealing a novel post-transcriptional regulation ofIK.ACh. (Circ J 2016; 80: 1346-1355).  (日)    [継承]
キーワード (推奨): 1. (英) Aged (日) (読) [継承]
2. (英) Atrial Fibrillation (日) (読) [継承]
3. (英) Case-Control Studies (日) (読) [継承]
4. (英) Cells, Cultured (日) (読) [継承]
5. (英) Down-Regulation (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7. (英) GTP-Binding Proteins (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Male (日) (読) [継承]
10. (英) MicroRNAs (日) (読) [継承]
11. (英) Middle Aged (日) (読) [継承]
12. (英) Myocytes, Cardiac (日) (読) [継承]
13. (英) Potassium Channels, Inwardly Rectifying (日) (読) [継承]
14. (英) Potassium Channels, Voltage-Gated (日) (読) [継承]
15. (英) Up-Regulation (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Circulation Journal ([社団法人 日本循環器学会])
(pISSN: 1346-9843, eISSN: 1347-4820)

ISSN (任意): 1347-4820
ISSN: 1346-9843 (pISSN: 1346-9843, eISSN: 1347-4820)
Title: Circulation journal : official journal of the Japanese Circulation Society
Title(ISO): Circ J
Supplier: 社団法人日本循環器学会
Publisher: Japanese Circulation Society/Nihon Junkanki Gakkai
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 80 [継承]
(必須): 6 [継承]
(必須): 1346 1355 [継承]
都市 (任意):
年月日 (必須): 西暦 2016年 5月 25日 (平成 28年 5月 25日) [継承]
URL (任意):
DOI (任意): 10.1253/circj.CJ-15-1276    (→Scopusで検索) [継承]
PMID (任意): 27180889    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意): 2-s2.0-84969731123 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.ELocationID: 10.1253/circj.CJ-15-1276  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Masaki Morishima, Eriko Iwata, Chisato Nakada, Yoshiyuki Tsukamoto, Hiroki Takanari, Shinji Miyamoto, Masatsugu Moriyama and Katsushige Ono : Atrial Fibrillation-Mediated Upregulation of miR-30d Regulates Myocardial Electrical Remodeling of the G-Protein-Gated K(+) Channel, IK.ACh., Circulation Journal, Vol.80, No.6, 1346-1355, 2016.
欧文冊子 ● Masaki Morishima, Eriko Iwata, Chisato Nakada, Yoshiyuki Tsukamoto, Hiroki Takanari, Shinji Miyamoto, Masatsugu Moriyama and Katsushige Ono : Atrial Fibrillation-Mediated Upregulation of miR-30d Regulates Myocardial Electrical Remodeling of the G-Protein-Gated K(+) Channel, IK.ACh., Circulation Journal, Vol.80, No.6, 1346-1355, 2016.

関連情報

Number of session users = 2, LA = 0.41, Max(EID) = 383335, Max(EOID) = 1024622.