『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=329477)

EID=329477EID:329477, Map:0, LastModified:2017年8月17日(木) 16:54:06, Operator:[藤野 裕道], Avail:TRUE, Censor:0, Owner:[藤野 裕道], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術レター (ショートペーパー) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.藤野 裕道 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.生命薬理学])
役割 (任意):
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学籍番号 (推奨):
[継承]
2. (英) Regan J W (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) FP prostanoid receptor activation of a T-cell factor/beta -catenin signaling pathway.  (日)    [継承]
副題 (任意):
要約 (任意): (英) FP prostanoid receptors are G-protein-coupled receptors (GPCR) that consist of two known isoforms, FP(A) and FP(B). These isoforms, which are generated by alternative mRNA splicing, are identical except for their carboxyl-terminal domains. Previously we have shown that stimulation of both isoforms with prostaglandin F(2alpha) (PGF(2alpha)) activates the small G-protein Rho, leading to morphological changes consisting of cell rounding and the formation of cell aggregates. Following the removal of PGF(2alpha), however, FP(A)-expressing cells show rapid reversal of cell rounding, whereas FP(B)-expressing cells do not. We now show that acute treatment of FP(B)-expressing cells with PGF(2alpha) leads to a subcellular reorganization of beta-catenin, a decrease in the phosphorylation of cytoplasmic beta-catenin, and persistent stimulation of Tcf/Lef-mediated transcriptional activation. This does not occur in FP(A)-expressing cells and may underlie the differences between these isoforms with respect to the reversal of cell rounding. The Tcf/beta-catenin signaling pathway is known to mediate the actions of Wnt acting through the heptahelical receptor, Frizzled, and has not been associated previously with GPCR activation. Our findings expand the signaling possibilities for GPCRs and suggest novel roles for FP receptors in normal tissue development and malignant transformation.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cell Line (日) (読) [継承]
3. (英) Cell Nucleus (日) (読) [継承]
4. (英) Cytoskeletal Proteins (日) (読) [継承]
5. (英) Cytosol (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Phosphorylation (日) (読) [継承]
8. (英) Protein Isoforms (日) (読) [継承]
9. (英) Receptors, Prostaglandin (日) (読) [継承]
10. (英) Recombinant Proteins (日) (読) [継承]
11. (英) Sheep (日) (読) [継承]
12. (英) Signal Transduction (日) (読) [継承]
13. (英) Trans-Activators (日) (読) [継承]
14. (英) Transfection (日) (読) [継承]
15. (英) Transforming Growth Factor beta (日) (読) [継承]
16. (英) beta Catenin (日) (読) [継承]
17. (英) rho GTP-Binding Proteins (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Biological Chemistry ([The American Society for Biochemistry and Molecular Biology])
(pISSN: 0021-9258, eISSN: 1083-351X)

ISSN (任意): 0021-9258
ISSN: 0021-9258 (pISSN: 0021-9258, eISSN: 1083-351X)
Title: The Journal of biological chemistry
Title(ISO): J Biol Chem
Publisher: American Society for Biochemistry and Molecular Biology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 276 [継承]
(必須): 16 [継承]
(必須): 12489 12492 [継承]
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年月日 (必須): 西暦 2001年 2月 13日 (平成 13年 2月 13日) [継承]
URL (任意):
DOI (任意): 10.1074/jbc.C100039200    (→Scopusで検索) [継承]
PMID (任意): 11278257    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Comparative Study  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) PublicationType: Research Support, U.S. Gov't, P.H.S.  (日)    [継承]

標準的な表示

和文冊子 ● Hiromichi Fujino and W J Regan : FP prostanoid receptor activation of a T-cell factor/beta -catenin signaling pathway., The Journal of Biological Chemistry, Vol.276, No.16, 12489-12492, 2001.
欧文冊子 ● Hiromichi Fujino and W J Regan : FP prostanoid receptor activation of a T-cell factor/beta -catenin signaling pathway., The Journal of Biological Chemistry, Vol.276, No.16, 12489-12492, 2001.

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