『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=329473EID:329473, Map:0, LastModified:2017年8月17日(木) 16:52:19, Operator:[藤野 裕道], Avail:TRUE, Censor:0, Owner:[藤野 裕道], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.藤野 裕道 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.生命薬理学])
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2. (英) Srinivasan Dinesh (日) (読)
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3. (英) Regan John W (日) (読)
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題名 (必須): (英) Cellular conditioning and activation of beta-catenin signaling by the FPB prostanoid receptor.  (日)    [継承]
副題 (任意):
要約 (任意): (英) FP prostanoid receptors have been identified as two isoforms named FP(A) and FP(B). We have shown that the FP(B) isoform, but not the FP(A), activates beta-catenin-mediated transcription. We now report that the mechanism of this FP(B)-specific activation of beta-catenin signaling occurs in two steps. The first is a conditioning step that involves an agonist-independent association of the FP(B) receptor with phosphatidylinositol 3-kinase followed by constitutive internalization of a receptor complex containing E-cadherin and beta-catenin. This constitutive internalization conditions the cell for subsequent beta-catenin signaling by increasing the cellular content of cytosolic beta-catenin. The second step involves agonist-dependent activation of Rho followed by cell rounding. Because of the conditioning step, this agonist-dependent step results in a stabilization of beta-catenin and activation of transcription. Although stimulation of the FP(A) isoform activates Rho and induces cellular shape change, it does not activate beta-catenin signaling, because the FP(A) does not undergo constitutive internalization and does not condition the cell for beta-catenin signaling. The cellular conditioning described here for the FP(B) illustrates the potential of the receptor to alter the signaling environment of a cell even in the absence of agonist and has general significance for understanding G-protein-coupled receptor signaling.  (日)    [継承]
キーワード (推奨): 1. (英) Androstadienes (日) (読) [継承]
2. (英) Cell Line (日) (読) [継承]
3. (英) Cytoskeletal Proteins (日) (読) [継承]
4. (英) Cytosol (日) (読) [継承]
5. (英) Dinoprost (日) (読) [継承]
6. (英) Fluorescent Antibody Technique (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Phosphatidylinositol 3-Kinases (日) (読) [継承]
9. (英) Receptors, Prostaglandin (日) (読) [継承]
10. (英) Signal Transduction (日) (読) [継承]
11. (英) Trans-Activators (日) (読) [継承]
12. (英) beta Catenin (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Biological Chemistry ([The American Society for Biochemistry and Molecular Biology])
(pISSN: 0021-9258, eISSN: 1083-351X)

ISSN (任意): 0021-9258
ISSN: 0021-9258 (pISSN: 0021-9258, eISSN: 1083-351X)
Title: The Journal of biological chemistry
Title(ISO): J Biol Chem
Publisher: American Society for Biochemistry and Molecular Biology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 277 [継承]
(必須): 50 [継承]
(必須): 48786 48795 [継承]
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年月日 (必須): 西暦 2002年 10月 3日 (平成 14年 10月 3日) [継承]
URL (任意):
DOI (任意): 10.1074/jbc.M209393200    (→Scopusで検索) [継承]
PMID (任意): 12368277    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
3.(英) PublicationType: Research Support, U.S. Gov't, P.H.S.  (日)    [継承]

標準的な表示

和文冊子 ● Hiromichi Fujino, Dinesh Srinivasan and W John Regan : Cellular conditioning and activation of beta-catenin signaling by the FPB prostanoid receptor., The Journal of Biological Chemistry, Vol.277, No.50, 48786-48795, 2002.
欧文冊子 ● Hiromichi Fujino, Dinesh Srinivasan and W John Regan : Cellular conditioning and activation of beta-catenin signaling by the FPB prostanoid receptor., The Journal of Biological Chemistry, Vol.277, No.50, 48786-48795, 2002.

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