『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=329443EID:329443, Map:0, LastModified:2018年12月5日(水) 16:26:13, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[藤野 裕道], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Shimizu Masaya (日) (読)
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2. (英) Muramatsu Yuki (日) (読)
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3. (英) Tada Eiko (日) (読)
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4. (英) Kurosawa Takeshi (日) (読)
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5. (英) Yamaura Erika (日) (読)
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6. (英) Nakamura Hiroyuki (日) (読)
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7.藤野 裕道 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.生命薬理学])
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8. (英) Houjyo Yuuya (日) (読)
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9. (英) Miyasaka Yuri (日) (読)
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10. (英) Koide Yuuki (日) (読)
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11. (英) Nishida Atsushi (日) (読)
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12. (英) Murayama Toshihiko (日) (読)
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題名 (必須): (英) Effects of synthetic sphingosine-1-phosphate analogs on cytosolic phospholipase A2alpha-independent release of arachidonic acid and cell toxicity in L929 fibrosarcoma cells: the structure-activity relationship.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Sphingolipid metabolites including ceramide, sphingosine, and their phosphorylated products [sphingosine-1-phosphate (S1P) and ceramide-1-phosphate] regulate cell functions including arachidonic acid (AA) metabolism and cell death. The development of analogs of S1P may be useful for regulating these mediator-induced cellular responses. We synthesized new analogs of S1P and examined their effects on the release of AA and cell death in L929 mouse fibrosarcoma cells. Among the analogs tested, several compounds including DMB-mC11S [dimethyl (2S,3R)-2-tert-butoxycarbonylamino-3-hydroxy-3-(3'-undecyl)phenylpropyl phosphate] and DMB-mC9S [dimethyl (2S,3R)-2-tert-butoxycarbonylamino-3-hydroxy-3-(3'-nonyl)phenylpropyl phosphate] released AA within 1 h and caused cell death 6 h after treatment. The release of AA was observed in C12 cells [a L929 variant lacking a type alpha cytosolic phospholipase A(2) (cPLA(2)alpha)] and L929-cPLAalpha-siRNA cells (L929 cells treated with small interference RNA for cPLA(2)alpha). Treatment with pharmacological inhibitors of secretory and Ca(2+)-independent PLA(2)s decreased the DMB-mC11S-induced release of AA. The effect of the S1P analogs tested on the release of AA was comparable to that on cell death in L929 cells, and a high correlation coefficient was observed. Two analogs lacking a butoxycarbonyl moiety [DMAc-mC11S (dimethyl (2S,3R)-2-acetamino-3-hydroxy-3-(3'-undecyl)phenylpropyl phosphate] and DMAm-mC11S [dimethyl (2S,3R)-2-amino-3-hydroxy-3-(3'-undecyl)phenylpropyl phosphate)] had inhibitory effects on the release of AA and cell toxicity induced by DMB-mC11S. Synthetic phosphorylated lipid analogs may be useful for studying PLA(2) activity and its toxicity in cells. [Supplementary Fig. 1: available only at http://dx.doi.org/10.1254/jphs.08284FP].  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Arachidonic Acid (日) (読) [継承]
3. (英) Cell Death (日) (読) [継承]
4. (英) Cell Line, Tumor (日) (読) [継承]
5. (英) Fibrosarcoma (日) (読) [継承]
6. (英) Group IV Phospholipases A2 (日) (読) [継承]
7. (英) Lysophospholipids (日) (読) [継承]
8. (英) Mice (日) (読) [継承]
9. (英) RNA, Small Interfering (日) (読) [継承]
10. (英) Sphingosine (日) (読) [継承]
11. (英) Structure-Activity Relationship (日) (読) [継承]
12. (英) Time Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Pharmacological Sciences ([日本薬理学会])
(pISSN: 1347-8613, eISSN: 1347-8648)

ISSN (任意): 1347-8613
ISSN: 1347-8613 (pISSN: 1347-8613, eISSN: 1347-8648)
Title: Journal of pharmacological sciences
Title(ISO): J Pharmacol Sci
Supplier: 公益社団法人 日本薬理学会
Publisher: Elsevier BV
 (NLM Catalog  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 109 [継承]
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(必須): 431 443 [継承]
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年月日 (必須): 西暦 2009年 3月 11日 (平成 21年 3月 11日) [継承]
URL (任意):
DOI (任意): 10.1254/jphs.08284FP    (→Scopusで検索) [継承]
PMID (任意): 19276615    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Masaya Shimizu, Yuki Muramatsu, Eiko Tada, Takeshi Kurosawa, Erika Yamaura, Hiroyuki Nakamura, Hiromichi Fujino, Yuuya Houjyo, Yuri Miyasaka, Yuuki Koide, Atsushi Nishida and Toshihiko Murayama : Effects of synthetic sphingosine-1-phosphate analogs on cytosolic phospholipase A2alpha-independent release of arachidonic acid and cell toxicity in L929 fibrosarcoma cells: the structure-activity relationship., Journal of Pharmacological Sciences, Vol.109, No.3, 431-443, 2009.
欧文冊子 ● Masaya Shimizu, Yuki Muramatsu, Eiko Tada, Takeshi Kurosawa, Erika Yamaura, Hiroyuki Nakamura, Hiromichi Fujino, Yuuya Houjyo, Yuri Miyasaka, Yuuki Koide, Atsushi Nishida and Toshihiko Murayama : Effects of synthetic sphingosine-1-phosphate analogs on cytosolic phospholipase A2alpha-independent release of arachidonic acid and cell toxicity in L929 fibrosarcoma cells: the structure-activity relationship., Journal of Pharmacological Sciences, Vol.109, No.3, 431-443, 2009.

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