『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=329062)

EID=329062EID:329062, Map:0, LastModified:2017年12月15日(金) 10:18:52, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) [継承]
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院生物資源産業学研究部 (2016年4月1日〜) [継承]
著者 (必須): 1. (英) Ohkura Kazuto (日) (読)
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2. (英) Kawaguchi Yuki (日) (読)
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[継承]
3. (英) Tatematsu Y (日) (読)
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[継承]
4.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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[継承]
5.堀 均
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[継承]
題名 (必須): (英) An Antitumor 2-Hydroxyarylidene-4-cyclopentene-1,3-Dione as a Protein Tyrosine Kinase Inhibitor: Interaction Between TX-1123 Derivatives and Src Kinase  (日)    [継承]
副題 (任意):
要約 (任意): (英) Protein tyrosine kinases (PTKs) play major roles in signal transduction during cell proliferation and apoptosis. Tyrphostin AG17 was previously shown to be a potent tumor growth inhibitor, while AG17 induced apoptosis and inhibited activity of cyclin-dependent kinase 2. We herein describe the binding features of tyrphostin AG17 analogs, such as TX-1123, with Src kinase (Src-K).MATERIALS AND METHODS:Structural data for Src-K were obtained from a protein data bank (ID=2SRC), and the molecular interactions between Src-K and TX-1123 derivatives were examined.RESULTS:TX-1123 exihibited potent Src-K inhibitory activity (half maximal-inhibitory concentration=2.2 M), and fit into the pocket of the Src-K molecule as well as c-AMP did.CONCLUSION:The binding profiles of TX-1123 derivatives differed from each other, while their Src-K inhibitory activities were affected by their fit in the Src-K molecule.  (日)    [継承]
キーワード (推奨): 1. (英) Protein kinase (日) (読) [継承]
2. (英) TX-1123 derivative (日) (読) [継承]
3. (英) kinase inhibitor (日) (読) [継承]
発行所 (推奨): (英) International Institute of Anticancer Research (日) (読) [継承]
誌名 (必須): Anticancer Research (International Institute of Anticancer Research(IIAR))
(pISSN: 0250-7005, eISSN: 1791-7530)

ISSN (任意): 1791-7530
ISSN: 0250-7005 (pISSN: 0250-7005, eISSN: 1791-7530)
Title: Anticancer research
Title(ISO): Anticancer Res.
Publisher: International Institute of Anticancer Research
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 36 [継承]
(必須): 7 [継承]
(必須): 3645 3649 [継承]
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年月日 (必須): 西暦 2016年 7月 初日 (平成 28年 7月 初日) [継承]
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PMID (任意): 27354635    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-84992160339 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) KeywordList.Keyword: Protein kinase  (日)    [継承]
3.(英) KeywordList.Keyword: TX-1123 derivatives  (日)    [継承]
4.(英) KeywordList.Keyword: kinase inhibitor  (日)    [継承]

標準的な表示

和文冊子 ● Kazuto Ohkura, Yuki Kawaguchi, Y Tatematsu, Yoshihiro Uto and Hitoshi Hori : An Antitumor 2-Hydroxyarylidene-4-cyclopentene-1,3-Dione as a Protein Tyrosine Kinase Inhibitor: Interaction Between TX-1123 Derivatives and Src Kinase, Anticancer Research, Vol.36, No.7, 3645-3649, 2016.
欧文冊子 ● Kazuto Ohkura, Yuki Kawaguchi, Y Tatematsu, Yoshihiro Uto and Hitoshi Hori : An Antitumor 2-Hydroxyarylidene-4-cyclopentene-1,3-Dione as a Protein Tyrosine Kinase Inhibitor: Interaction Between TX-1123 Derivatives and Src Kinase, Anticancer Research, Vol.36, No.7, 3645-3649, 2016.

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