| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院生物資源産業学研究部 (2016年4月1日〜)
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| ○著者 (必須): | 1. | (英) Ohkura Kazuto (日) (読)
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| 2. | (英) Kawaguchi Yuki (日) (読)
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| 3. | (英) Tatematsu Y (日) (読)
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| 4. | 宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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| 5. | 堀 均
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| ○題名 (必須): | □ | (英) An Antitumor 2-Hydroxyarylidene-4-cyclopentene-1,3-Dione as a Protein Tyrosine Kinase Inhibitor: Interaction Between TX-1123 Derivatives and Src Kinase (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Protein tyrosine kinases (PTKs) play major roles in signal transduction during cell proliferation and apoptosis. Tyrphostin AG17 was previously shown to be a potent tumor growth inhibitor, while AG17 induced apoptosis and inhibited activity of cyclin-dependent kinase 2. We herein describe the binding features of tyrphostin AG17 analogs, such as TX-1123, with Src kinase (Src-K).MATERIALS AND METHODS:Structural data for Src-K were obtained from a protein data bank (ID=2SRC), and the molecular interactions between Src-K and TX-1123 derivatives were examined.RESULTS:TX-1123 exihibited potent Src-K inhibitory activity (half maximal-inhibitory concentration=2.2 M), and fit into the pocket of the Src-K molecule as well as c-AMP did.CONCLUSION:The binding profiles of TX-1123 derivatives differed from each other, while their Src-K inhibitory activities were affected by their fit in the Src-K molecule. (日)
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| ○キーワード (推奨): | 1. | (英) Protein kinase (日) (読)
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| 2. | (英) TX-1123 derivative (日) (読)
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| 3. | (英) kinase inhibitor (日) (読)
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| ○発行所 (推奨): | □ | (英) International Institute of Anticancer Research (日) (読)
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| ○誌名 (必須): | □ | Anticancer Research (International Institute of Anticancer Research(IIAR))
(pISSN: 0250-7005, eISSN: 1791-7530)
| ○ISSN (任意): | □ | 1791-7530
ISSN: 0250-7005
(pISSN: 0250-7005, eISSN: 1791-7530) Title: Anticancer researchTitle(ISO): Anticancer Res.Publisher: International Institute of Anticancer Research (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 36
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| ○号 (必須): | □ | 7
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| ○頁 (必須): | □ | 3645 3649
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 7月 初日 (平成 28年 7月 初日)
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| ○URL (任意): |
| ○DOI (任意): |
| ○PMID (任意): | □ | 27354635 (→Scopusで検索)
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| ○NAID (任意): |
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| ○Scopus (任意): | □ | 2-s2.0-84992160339
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) KeywordList.Keyword: Protein kinase (日)
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| 3. | (英) KeywordList.Keyword: TX-1123 derivatives (日)
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| 4. | (英) KeywordList.Keyword: kinase inhibitor (日)
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