| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): | □ | 博士課程学生による研究報告
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Hosokawa Yuki (日) (読)
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| 2. | 平尾 功治
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| 3. | 湯本 浩通 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯周歯内治療学])
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| 4. | (英) Washio Ayako (日) (読)
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| 5. | 中西 正 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.再生歯科治療学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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| 6. | 武川 大輔 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.再生歯科治療学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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| 7. | (英) Kitamura Chiaki (日) (読)
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| 8. | 松尾 敬志
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| ○題名 (必須): | □ | (英) Functional roles of NOD1 in odontoblasts on dental pulp innate immunity (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Caries-related pathogens are first recognized by odontoblasts and induce inflammatory events that develop to pulpitis. Generally, initial sensing of microbial pathogens is mediated by pattern recognition receptors, such as Toll-like receptor and nucleotide-binding oligomerization domain (NOD); however, little is known about NODs in odontoblasts. In this study, the levels of NODs expressed in rat odontoblastic cell line, KN-3, were assessed by flow cytometry and the levels of chemokines in NOD-specific ligand-stimulated KN-3 cells were analyzed by real-time PCR and ELISA. The signal transduction pathway activated with NOD-specific ligand was assessed by blocking assay with specific inhibitors and reporter assay. In KN-3 cells, the expression level of NOD1 was stronger than that of NOD2 and the production of chemokines, such as CINC-1, CINC-2, CCL20, and MCP-1, was upregulated by stimulation with NOD1-specific ligand, but not with NOD2-specific ligand. CINC-2 and CCL20 production by stimulation with NOD1-specific ligand was reduced by p38 MAPK and AP-1 signaling inhibitors. Furthermore, the reporter assay demonstrated AP-1 activation in NOD1-specific ligand-stimulated KN-3 cells. These findings indicated that NOD1 expressed in odontoblasts functions to upregulate the chemokines expression via p38-AP-1 signaling pathway and suggested that NOD1 may play important roles in the initiation and progression of pulpitis. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Cell Line (日) (読)
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| 3. | 細胞質分裂 (cytokinesis)
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| 4. | (英) Dental Pulp (日) (読)
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| 5. | 自然免疫 (innate immunity)
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| 6. | (英) Inflammation Mediators (日) (読)
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| 7. | (英) Nod1 Signaling Adaptor Protein (日) (読)
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| 8. | (英) Odontoblasts (日) (読)
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| 9. | (英) Rats (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | BioMed Research International (Hindawi Pub. Co.)
(pISSN: 2314-6133, eISSN: 2314-6141)
| ○ISSN (任意): | □ | 2314-6141
ISSN: 2314-6133
(pISSN: 2314-6133, eISSN: 2314-6141) Title: BioMed research internationalTitle(ISO): Biomed Res IntPublisher: Hindawi (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 2016
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 9325436 9325436
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 9月 25日 (平成 28年 9月 25日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1155/2016/9325436 (→Scopusで検索)
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| ○PMID (任意): | □ | 27747243 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-84991669747
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| ○機関リポジトリ : | □ | 112386
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) CoiStatement: The authors declare that there is no conflict of interest regarding the publication of this paper. (日)
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