『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=327279)

EID=327279EID:327279, Map:0, LastModified:2022年3月25日(金) 11:14:21, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[徳島大学.大学院医歯薬学研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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組織 (推奨): 1.徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔微生物学 (2015年4月1日〜) [継承]
著者 (必須): 1.天羽 崇
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学籍番号 (推奨): **** [ユーザ]
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2.村上 圭史
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3. (英) Kariyama Reiko (日) (読)
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4. (英) Hori Kenji (日) (読)
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5. (英) Irie Yasuhiko (日) (読)
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6. (英) Viducic Darija (日) (読)
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7.弘田 克彦
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8. (英) Igarashi Jun (日) (読)
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9. (英) Suga Hiroaki (日) (読)
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10. (英) Kumon Hiromi (日) (読)
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11.三宅 洋一郎
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題名 (必須): (英) A Pseudomonas aeruginosa Quorum-Sensing autoinducer analog enhances the activity of antibiotics against resistant strains.  (日)    [継承]
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要約 (任意): (英) In this study, we have investigated the effects of the newly synthesized analog of Pseudomonas aeruginosa quorum-sensing autoinducer named AIA-1 (autoinducer analog) against antibiotic-resistant bacteria. In vitro susceptibility and killing assays for P. aeruginosa PAO1 prD mutant and clinical isolates were performed by using antibiotics and AIA-1. In an in vivo assay, a luminescent carbapenem-resistant strain derived from PAO1 prD was injected into neutropenic ICR mice and bioluminescence images were acquired after the treatment with antibiotics and AIA-1. Additionally, we investigated the effects of the combination use against carbapenem-resistant Enterobacteriaceae (CRE). Using killing assays in P. aeruginosa, the survival rates in the presence of antibiotics and AIA-1 significantly decreased in comparison with those with antibiotics alone. Furthermore, dual treatment of biapenem and AIA-1 was more effective than biapenem alone in a mouse infection model. AIA-1 did not change the MICs in P. aeruginosa, suggesting that AIA-1 acts on the mechanism of antibiotic tolerance. Conversely, the MICs of antibiotics decreased in the presence of AIA-1 in some CRE strains, indicating that AIA-1 may require additional mechanism to act on CRE. In conclusion, AIA-1 may be a potent drug for clinical treatment of infections caused by antibiotic-resistant bacteria. J. Med. Invest. 64: 101-109, February, 2017.  (日)    [継承]
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誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1349-6867
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: University of Tokushima
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2017年 0月 初日 (平成 29年 0月 初日) [継承]
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DOI (任意): 10.2152/jmi.64.101    (→Scopusで検索) [継承]
PMID (任意): 28373605    (→Scopusで検索) [継承]
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機関リポジトリ : 111094 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.2152/jmi.64.101  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Takashi Amoh, Keiji Murakami, Reiko Kariyama, Kenji Hori, Yasuhiko Irie, Darija Viducic, Katsuhiko Hirota, Jun Igarashi, Hiroaki Suga, Hiromi Kumon and Yoichiro Miyake : A Pseudomonas aeruginosa Quorum-Sensing autoinducer analog enhances the activity of antibiotics against resistant strains., The Journal of Medical Investigation : JMI, Vol.64, No.1.2, 101-109, 2017.
欧文冊子 ● Takashi Amoh, Keiji Murakami, Reiko Kariyama, Kenji Hori, Yasuhiko Irie, Darija Viducic, Katsuhiko Hirota, Jun Igarashi, Hiroaki Suga, Hiromi Kumon and Yoichiro Miyake : A Pseudomonas aeruginosa Quorum-Sensing autoinducer analog enhances the activity of antibiotics against resistant strains., The Journal of Medical Investigation : JMI, Vol.64, No.1.2, 101-109, 2017.

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