| ○種別 (必須): | □ | 総説·解説
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| ○言語 (必須): | □ | 英語
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| ○組織 (推奨): | 1. | 徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学 (2015年4月1日〜)
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| ○著者 (必須): | 1. | 齋藤 雅子
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| 2. | (英) Otsuka Kunihiro (日) 大塚 邦紘 (読) おおつか くにひろ
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| ○学籍番号 (推奨): | □ | ****
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| 3. | (英) Ushio Aya (日) 牛尾 綾 (読) うしお あや
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| ○学籍番号 (推奨): | □ | ****
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| 4. | 山田 安希子
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| 5. | 新垣 理恵子
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| 6. | 工藤 保誠 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])
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| 7. | 石丸 直澄 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])
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| ○題名 (必須): | □ | (英) Unique Phenotypes and Functions of Follicular Helper T Cell and Regulatory T Cell in Sjögren's Syndrome. (日)
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| ○要約 (任意): | □ | (英) Sjögren's syndrome (SS) is a T cell-mediated autoimmune disease of the systemic exocrine glands, such as salivary and lacrimal glands. A variety of T-cell subpopulations maintain immune tolerance in the thymus and periphery through complex immune responses including cellular and humoral immunity. The T-cell subpopulations exhibiting abnormal or unique phenotypes and impaired functionality have been reported to play important roles in the cellular mechanisms of autoimmunity in SS patients and animal models of SS. In this review, we focused on follicular helper T cells related to antibody production and regulatory T cells to control immune tolerance in the pathogenesis of SS. The unique roles of these T-cell subpopulations in the process of the onset or development of SS have been demonstrated in this review of recent publications. The clinical application of these T-cell subpopulations will be helpful for the development of new techniques for diagnosis or treatment of SS in the future. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Autoimmunity (日) (読)
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| 3. | (英) Disease Models, Animal (日) (読)
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| 4. | (英) Humans (日) (読)
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| 5. | (英) Immune Tolerance (日) (読)
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| 6. | (英) Lymph Nodes (日) (読)
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| 7. | (英) Phenotype (日) (読)
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| 8. | (英) Sjogren's Syndrome (日) (読)
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| 9. | (英) T-Lymphocytes, Helper-Inducer (日) (読)
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| 10. | (英) T-Lymphocytes, Regulatory (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Current Rheumatology Reviews (Bentham Science Publishers)
(pISSN: 1573-3971, eISSN: 1875-6360)
| ○ISSN (任意): | □ | 1875-6360
ISSN: 1573-3971
(pISSN: 1573-3971, eISSN: 1875-6360) Title: Current rheumatology reviewsTitle(ISO): Curr Rheumatol RevPublisher: Bentham Science Publishers (NLM Catalog)
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| ○巻 (必須): | □ | 14
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 239 245
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2017年 1月 25日 (平成 29年 1月 25日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.2174/1573397113666170125122858 (→Scopusで検索)
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| ○PMID (任意): | □ | 28124612 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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