| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○組織 (推奨): | 1. | 徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学 (2015年4月1日〜)
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| ○著者 (必須): | 1. | 牛尾 綾 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])
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| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 2. | 新垣 理恵子
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| 3. | 江口 洋
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| 4. | (英) Hotta Fumika (日) (読)
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| 5. | 山田 安希子
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| 6. | 工藤 保誠 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])
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| 7. | 石丸 直澄 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])
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| ○題名 (必須): | □ | (英) Pathological Analysis of Ocular Lesions in a Murine Model of Sjögren's Syndrome. (日)
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| ○要約 (任意): | □ | (英) Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by severe inflammation of exocrine glands such as the salivary and lacrimal glands. When it affects the lacrimal glands, many patients experience keratoconjunctivitis due to severely dry eyes. This study investigated the pathological and immunological characteristics of ocular lesions in a mouse model of SS. Corneal epithelial injury and hyperplasia were confirmed pathologically. The number of conjunctival mucin-producing goblet cells was significantly decreased in the SS model mice compared with control mice. Expression levels of transforming growth factor (TGF)-, interleukin (IL)-6, tumor necrosis factor (TNF)-, and C-X-C motif chemokine (CXCL) 12 were significantly higher in the corneal epithelium of the SS model mice than in control mice. Inflammatory lesions were observed in the Harderian, intraorbital, and extraorbital lacrimal glands in the SS model mice, suggesting that the ocular glands were targeted by an autoimmune response. The lacrimal glands of the SS model mice were infiltrated by cluster of differentiation (CD)4+ T cells. Real-time reverse transcription-polymerase chain reaction (RT-PCR) revealed significantly increased mRNA expression of TNF-, TGF-, CXCL9, and lysozyme in the extraorbital lacrimal glands of the SS model mice compared with control mice. These results add to the understanding of the complex pathogenesis of SS and may facilitate development of new therapeutic strategies. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | International Journal of Molecular Sciences (Molecular Diversity Preservation International/Multidisciplinary Digital Publishing Institute)
(pISSN: 1661-6596, eISSN: 1422-0067)
| ○ISSN (任意): | □ | 1422-0067
ISSN: 1661-6596
(pISSN: 1661-6596, eISSN: 1422-0067) Title: International journal of molecular sciencesTitle(ISO): Int J Mol SciPublisher: Multidisciplinary Digital Publishing Institute (MDPI) (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 18
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| ○号 (必須): | □ | 6
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| ○頁 (必須): |
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| ○年月日 (必須): | □ | 西暦 2017年 6月 6日 (平成 29年 6月 6日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3390/ijms18061209 (→Scopusで検索)
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| ○PMID (任意): | □ | 28587293 (→Scopusで検索)
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| ○機関リポジトリ : | □ | 110971
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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